Evidence map›Paper›PMID 41811422›Full record

ArticleIndian pediatrics2026

Evaluation of HLA-DQ Genetic Risk Classes in Pediatric Cases for Celiac Disease: Role of HLA-DQ2 and DQ8 Haplotypes.

Hatice Yilmaz Dagli, Reha Artan, Aygen Yılmaz

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Article in Indian pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Hatice Yilmaz DagliDepartment of Pediatric Gastroenterology, Akdeniz University, Antalya, Turkey. htc.ylmzdgl@gmail.com.ORCID http://orcid.org/0000-0003-3835-9775
Reha ArtanDepartment of Pediatric Gastroenterology, Akdeniz University, Antalya, Turkey.ORCID http://orcid.org/0000-0001-6114-9210
Aygen YılmazDepartment of Pediatric Gastroenterology, Akdeniz University, Antalya, Turkey.ORCID http://orcid.org/0000-0003-4051-8069

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo determine the human leukocyte antigen (HLA)-DQ genotype pattern in children with celiac disease (CD).

methodsWe retrospectively reviewed 490 patients aged 2-18 years who presented to our clinic between 2014 and 2024 with suspected CD and underwent HLA-DQ tissue typing.

resultsOut of 490 patients, 220 were diagnosed as CD and 270 as controls. Analysis of CD samples for HLA types revealed that 140 (63.6%) were only HLA-DQ2 positive, 25 (11.3%) were only HLA-DQ8 positive, and 35 (15.9%) were both HLA-DQ2 and HLA-DQ8 positive. However, 20 (9%) of our patients were neither HLA-DQ2 nor HLA-DQ8 positive. In the control group, 102 patients were HLA-DQ2 positive and 66 were HLA-DQ8 positive Being homozygous for HLA-DQ2 increased the risk for CD by 16.49 times, and being homozygous for HLA-DQ8 increased the risk for CD by 4.39 times.

conclusionsHLA-DQ2/8 genotypes are strongly associated with pediatric patients with CD in Turkey. These genotypes and their combinations do not alter clinical presentation. HLA-DQ2/8 strongly contributes to the development of CD.

Indexed as

Celiac DiseaseGenetic Predisposition to DiseaseHLA-DQ AntigensAdolescentChildChild, PreschoolFemaleGenotypeHaplotypesHumansMaleRetrospective StudiesTurkeyHLA-DQ2 antigenHLA-DQ8 antigenHLA-DQ AntigensCeliac diseaseHLA-DQ2HLA-DQ8Human leukocyte antigen

Identifiers

PMID41811422

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.