Evidence map›Paper›PMID 41811415›Full record

ArticleBulletin of experimental biology and medicine2025

Analysis of the Protective Mechanism of PGC-1α/NRF1/2/TFAM Pathway in Cortical Neuron Injury Induced by Oxidative Stress.

Jianhua Li, Wenshi Zhang, Wenqiang Hu, Wei Gao, Jian Wang, Jing Li, Yanxia Wang, Weikai Wang, Hongxia Gao, Bin Yi

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Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jianhua LiGansu Provincial Maternity and Child-Care Hospital, Lanzhou, China.
Wenshi ZhangGansu Provincial Maternity and Child-Care Hospital, Lanzhou, China.
Wenqiang HuGansu Provincial Maternity and Child-Care Hospital, Lanzhou, China.
Wei GaoHeshui County People's Hospital, Qingyang, China.
Jian WangGansu Provincial Maternity and Child-Care Hospital, Lanzhou, China.
Jing LiGansu Provincial Maternity and Child-Care Hospital, Lanzhou, China.
Yanxia WangGansu Provincial Maternity and Child-Care Hospital, Lanzhou, China.
Weikai WangGansu Provincial Maternity and Child-Care Hospital, Lanzhou, China.
Hongxia GaoGansu Provincial Maternity and Child-Care Hospital, Lanzhou, China. 657928305@qq.com.
Bin YiGansu Provincial Maternity and Child-Care Hospital, Lanzhou, China. www.0931@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To develop the theoretical basis for neuronal antioxidant therapy, the study employed in vitro model of oxidative stress of cortical neurons in order to examine the repair mechanisms triggered in the damaged neurons by PGC-1α/NRF1/NRF2/TFAM signal pathway. The functions of proteins in this signal pathway were examined using online STRING software, which analyzed the network of protein-protein interactions (PPI). The hub genes in PGC-1α/NRF1/NRF2/TFAM signal pathway were analyzed with Cytoscape software. In vitro, the cortical neurons were treated with 25, 50, 75, or 100 μM H

Indexed as

DNA-Binding ProteinsNeuronsNF-E2-Related Factor 1NF-E2-Related Factor 2Nuclear Respiratory Factor 1Oxidative StressPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaTranscription FactorsAnimalsApoptosisCells, CulturedCerebral CortexHydrogen PeroxideMembrane Potential, MitochondrialMiceMitochondriaDNA-Binding ProteinsHydrogen PeroxideNF-E2-Related Factor 1NF-E2-Related Factor 2Nuclear Respiratory Factor 1Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPpargc1a protein, mousePpargc1a protein, ratReactive Oxygen SpeciesTranscription FactorsNRF1NRF2oxidative stress; neuron; mitochondria function; PGC-1αTFAM pathway

Identifiers

PMID41811415

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.