Evidence map›Paper›PMID 41811408›Full record

ArticleBulletin of experimental biology and medicine2025

Modeling Endometriosis in Mice and Pharmacological Activity of the Drug Endoferin.

A V Ilyichev, M V Belopolskaya, V V Pavshintsev, D A Areshidze, A A Bustios-Guryanova, M L Lovat, L M Mikhaleva

Abstract read
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In one paragraph

Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

A V IlyichevAvtsyn Research Institute of Human Morphology, Petrovsky National Research Center of Surgery, Moscow, Russia. alex730110@gmail.com.
M V BelopolskayaResearch Institute of Mitoengineering of the Lomonosov Moscow State University LLC, Moscow, Russia.
V V PavshintsevPeoples' Friendship University of Russia Named after Patrice Lumumba (RUDN University), Moscow, Russia.
D A AreshidzeAvtsyn Research Institute of Human Morphology, Petrovsky National Research Center of Surgery, Moscow, Russia.
A A Bustios-GuryanovaResearch Institute of Mitoengineering of the Lomonosov Moscow State University LLC, Moscow, Russia.
M L LovatLomonosov Moscow State University, Moscow, Russia.
L M MikhalevaAvtsyn Research Institute of Human Morphology, Petrovsky National Research Center of Surgery, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A murine model of endometriosis was employed to evaluate the pharmacological efficacy of therapeutic compounds. Endometriosis was modeled by autotransplantation of uterine horn fragments onto the intestinal mesentery in three experimental paradigms: 1) with subcutaneous administration of estradiol; 2) a short-term protocol without estradiol; 3) a prolonged protocol without estradiol and with delayed administration of the test compound. In all animals, well-demarcated, rounded endometriotic lesions (endometriomas) were consistently observed at the implantation sites. Endoferin demonstrated its highest efficacy under the short-term, hormone-free protocol. The administration of exogenous estradiol interfered with the manifestation of the pharmacological activity of the test drug. Thus, a rapid in vivo method for assessing the therapeutic efficacy of candidate drugs was developed.

Indexed as

EndometriosisAnimalsDisease Models, AnimalEndometriumEstradiolFemaleMiceUterusEstradiolEndoferinendometriosisestradiolmice

Identifiers

PMID41811408

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.