ArticleBulletin of experimental biology and medicine2025
Effects of the Dihydroquercetin on Respiratory Parameters of Liver Mitochondria in Rats under Conditions of Hypothermia.
Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Hypothermia is accompanied by the development of a number of pathological processes, many of these are associated with mitochondrial dysfunction. Plant polyphenols, in particular, dihydroquercetin, can act as therapeutic agents with a mitoprotective effect. We studied the effects of dihydroquercetin on the respiratory parameters of rat liver mitochondria under conditions of moderate hypothermia. A 5-day course of dihydroquercetin (100 mg/kg) had a significant protective effect on the bioenergetics of the liver mitochondria in hypothermic rats, which was seen from a decrease in mitochondrial proton leakage and increased affinity of the respiratory chain to ADP and oxidation-phosphorylation coupling.
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