Evidence map›Paper›PMID 41811390›Full record

ArticleAnnals of surgical oncology2026

Impact of Ethnicity on the Uptake of Risk Reducing Mastectomy in Unaffected BRCA1/2 and PALB2 Carriers in Canada.

Sarah Mashal, Amel Melanson, Carla Apostolova, Amina Ferroum, Victor Villareal-Corpuz, Sarkis Meterissian, Karyne Martel, Jean-François Boileau, Mark Basik, William Foulkes and 2 more

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Article in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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5 · Who and what money

Authors and funding

12 authors.

Sarah MashalFaculty of Medicine & Health Sciences, McGill University, Montreal, QC, Canada.
Amel MelansonFaculty of Medicine & Health Sciences, McGill University, Montreal, QC, Canada.
Carla ApostolovaDepartment of Surgery, Division of General Surgery, McGill University, Montreal, QC, Canada.
Amina FerroumDepartment of Surgery, Division of Cardiac Surgery, McGill University, Montreal, QC, Canada.
Victor Villareal-CorpuzLady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, Montreal, QC, Canada.
Sarkis MeterissianDepartment of Surgery, Division of General Surgery, McGill University, Montreal, QC, Canada.
Karyne MartelDepartment of Surgery, Division of General Surgery, McGill University, Montreal, QC, Canada.
Jean-François BoileauDepartment of Surgery, Division of General Surgery, McGill University, Montreal, QC, Canada.
Mark BasikDepartment of Surgery, Division of General Surgery, McGill University, Montreal, QC, Canada.
William FoulkesDepartment of Medicine, Division of Oncology & Human Genetics, McGill University, Montreal, QC, Canada.
Stephanie M Wong *Department of Surgery, Division of General Surgery, McGill University, Montreal, QC, Canada.
Ipshita Prakash *Department of Surgery, Division of General Surgery, McGill University, Montreal, QC, Canada. ipshita.prakash@mcgill.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWhile several studies have reported on factors influencing the uptake of risk-reducing mastectomy (RRM) in patients with germline pathogenic variants (gPV) in BRCA1/2, there remains a paucity of data regarding variations in uptake by ethnicity.

methodsWe conducted a retrospective cohort study of unaffected female patients with a confirmed gPV in BRCA1/2 or PALB2 between March 2000 to March 2023 at two academic institutions in Montreal, Canada. Ethnicity was self-reported as: White/European, Black/African/Caribbean, Asian/Southeast Asian, Hispanic/South/Central American, Middle Eastern/North African, Indigenous/First Nations, or mixed. Fisher's exact test and multivariable logistic regression were used to evaluate predictors of RRM uptake.

resultsOf 476 unaffected female carriers, 205 (43.1%) had a gPV in BRCA1, 250 (52.5%) in BRCA2, and 21 (4.4%) in PALB2. The median age at genetic testing was 37 years (interquartile range [IQR], 29-47) and 365 (76.7%) patients were of White ethnicity. At a median follow-up of 49 months (IQR, 17-87), 182 (38.2%) women underwent RRM. Univariate analysis showed highest RRM uptake in Hispanic/South/Central American carriers (58.8%) and White carriers (40.3%) and lowest uptake in Black/African/Caribbean carriers (11.1%; p = 0.047). In adjusted analyses, ethnicity did not remain independently associated with RRM (p = 0.21), although age and family history of ovarian cancer did.

conclusionsIn this study of unaffected BRCA1/2 and PALB2 carriers, RRM uptake was lowest among Black/African/Caribbean carriers. However, ethnicity was not significantly associated with uptake of RRM in adjusted analyses. Further studies are needed to understand disparities in risk-reduction uptake and the complex decision-making process.

Indexed as

BRCA1 ProteinBRCA2 ProteinBreast NeoplasmsEthnicityFanconi Anemia Complementation Group N ProteinProphylactic MastectomyAdultCanadaFemaleFollow-Up StudiesGenetic Predisposition to DiseaseGerm-Line MutationHeterozygoteHumansMiddle AgedPrognosisBRCA1 ProteinBRCA1 protein, humanBRCA2 ProteinBRCA2 protein, humanFanconi Anemia Complementation Group N ProteinPALB2 protein, humanBRCA1/2Ethnic disparitiesGenetic testingPALB2Risk reducing mastectomy

Identifiers

PMID41811390

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.