Evidence map›Paper›PMID 41811226›Full record

ArticleAlcohol, clinical & experimental research2026

Using machine learning to identify unique predictors of alcohol and cannabis impaired driving.

Brian H Calhoun, Brittney A Hultgren, Connor J McCabe, Isaac C Rhew, Mary E Larimer, Jason R Kilmer, Katarina Guttmannova

Abstract read
In one paragraph

Article in Alcohol, clinical & experimental research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Brian H CalhounDepartment of Psychiatry and Behavioral Sciences, Center for the Study of Health and Risk Behaviors, University of Washington, Seattle, Washington, USA.
Brittney A HultgrenDepartment of Psychiatry and Behavioral Sciences, Center for the Study of Health and Risk Behaviors, University of Washington, Seattle, Washington, USA.ORCID https://orcid.org/0000-0002-7181-5050
Connor J McCabeDepartment of Psychiatry and Behavioral Sciences, Center for the Study of Health and Risk Behaviors, University of Washington, Seattle, Washington, USA.
Isaac C RhewDepartment of Psychiatry and Behavioral Sciences, Center for the Study of Health and Risk Behaviors, University of Washington, Seattle, Washington, USA.ORCID https://orcid.org/0000-0001-9731-8776
Mary E LarimerDepartment of Psychiatry and Behavioral Sciences, Center for the Study of Health and Risk Behaviors, University of Washington, Seattle, Washington, USA.
Jason R KilmerDepartment of Psychiatry and Behavioral Sciences, Center for the Study of Health and Risk Behaviors, University of Washington, Seattle, Washington, USA.
Katarina GuttmannovaDepartment of Psychiatry and Behavioral Sciences, Center for the Study of Health and Risk Behaviors, University of Washington, Seattle, Washington, USA.

Funding

Covid-19 pandemic and changes in the prevalence, patterns, and trajectories of substance use and related health risk outcomes among young adults in WA State: Administrative supplement.R01DA057705 · NIDA · UNIVERSITY OF WASHINGTON · PI GUTTMANNOVA, KATARINA · 2022 to 2024
$1.3M
Machine learning methods for identifying person-level mechanisms of alcohol use among sexual and gender minority intersectionsR00AA030052 · NIAAA · UNIVERSITY OF WASHINGTON · PI Connor J McCabe · 2024 to 2026
$727k
NIAAA NIH HHS R00 AA030052NIAAA NIH HHS R00AA030052NIDA NIH HHS R01 DA057705NIDA NIH HHS R01DA057705Washington State Health Care Authority (Division of Behavioral Health and Recovery)
6 · The paper itself

Abstract

backgroundAlcohol- and cannabis-impaired driving remain major public health concerns, particularly among young adults. Although prior studies have identified numerous risk factors, most have focused on limited subsets of predictors, restricting a broader understanding of impaired driving. This study applied machine learning to identify salient predictors of alcohol- and cannabis-impaired driving from a wide range of candidate variables.

methodsData came from annual cross-sectional surveys of 18- to 25-year-olds participating in the Washington Young Adult Health Survey (2015-2022). Analyses were limited to two overlapping subsets of participants: those who reported past-month alcohol use for analyses predicting alcohol-impaired driving (N = 9852) and those who reported past-month cannabis use for analyses predicting cannabis-impaired driving (N = 4891). Regularized regression and random forests were used to identify the most salient predictors of each type of impaired driving from a large set of approximately 80 candidate variables. These methods were selected for their complementary strengths and their shared capacity for robust performance when handling high-dimensional data with potentially collinear predictors.

resultsFor likelihood of alcohol-impaired driving, top predictors included alcohol use frequency, participants' age, peak drinking quantity, age of alcohol initiation, full-time employment, and cannabis use frequency. For likelihood of cannabis-impaired driving, top predictors included cannabis use frequency, cannabis-related memory problems, simultaneous alcohol and cannabis use frequency, increased cannabis tolerance, and age of cannabis initiation.

conclusionsTwo complementary machine learning methods yielded convergent findings on the most salient predictors of impaired driving, increasing confidence in their validity. These methods provide a flexible alternative to traditional models for analyzing high-dimensional data and highlight recent use patterns, substance use disorder symptoms, and age of initiation as key priorities for prevention.

Indexed as

Alcohol DrinkingAutomobile DrivingDriving Under the InfluenceMachine LearningAdolescentAdultClassification AlgorithmsCross-Sectional StudiesFemaleHumansPrediction AlgorithmsPredictive Learning ModelsRandom ForestRisk FactorsWashingtonYoung Adultdriving under the influenceimpaired drivingmachine learningrandom forestregularization

Identifiers

PMID41811226
PMCPMC12981337

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.