ArticleCNS neuroscience & therapeutics2026
Network Disconnection Syndrome in Unruptured Brain Arteriovenous Malformations: A Multimodal Connectome Study.
Article in CNS neuroscience & therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Structure-Function Decoupling Across Cerebrovascular Diseases: A Convergent Network Phenotype Requiring Disease-Specific Interpretation.CNS neuroscience & therapeutics · 2026Article
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Authors and funding
12 authors.
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Abstract
backgroundCognitive impairment is a critical yet poorly understood complication of brain arteriovenous malformations (bAVM). While traditionally attributed to hemodynamic "steal" or focal tissue destruction, it remains unclear whether cognitive variability correlates with gross structural pathology or broader network disruption.
methodsWe recruited consecutive patients with unruptured bAVM at Huashan Hospital and matched healthy controls (2017-2020). We integrated lesion frequency mapping, surface-based morphometry, and Network Diffusion Modeling (NDM) to dissect the structure-function relationship in a cohort of bAVM patients compared to matched controls. We systematically evaluated the predictive value of three distinct damage metrics-gross lesion load, cortical morphological remodeling, and white matter structural connectivity-on global and domain-specific cognitive performance.
resultsPatients with bAVM exhibited significantly reduced global efficiency in structural networks (p < 0.05), which was a stronger predictor of cognitive decline than lesion volume. In contrast, global functional network topology was largely preserved. Although local functional reorganization was observed, characterized by increased inter-hemispheric synchronization, these adaptations did not prevent cognitive deficits. Notably, increased structure-function decoupling within high-order association networks (including frontoparietal and ventral attention systems) was significantly associated with executive and memory impairment.
conclusionsCognitive dysfunction in bAVM represents a disconnection syndrome caused by the disruption of long-range white matter tracts rather than local cortical pathology. The dissociation between structural damage and functional compensation highlights the limitations of conventional volumetric assessment. Preoperative connectome mapping, particularly of white matter integrity, may improve risk stratification and functional preservation strategies.
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