Evidence map›Paper›PMID 41810957›Full record

ArticlemBio2026

Comprehensive immune profiling reveals IFN-γ signaling in T cells mediates parasite phagocytosis in a rodent malaria model.

Sha-Sha Chen, Qingxin Yang, Yu Zhong, Defu Liu, Lifang Zhou, Han-Cheng Wei, Chang-Ling Li, Junwei Song, Yu-Hang Wang, Xiao Hu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sha-Sha Chen *Center of Infectious Diseases and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.ORCID 0009-0003-4331-8756
Qingxin Yang *Center of Infectious Diseases and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.ORCID 0000-0002-9685-6553
Yu ZhongCenter of Infectious Diseases and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Defu LiuKey Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, Chengdu, China.
Lifang ZhouKey Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, Chengdu, China.
Han-Cheng WeiCenter of Infectious Diseases and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Chang-Ling LiCenter of Infectious Diseases and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Junwei SongKey Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, Chengdu, China.
Yu-Hang WangCenter of Infectious Diseases and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Xiao HuKey Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, Chengdu, China.
Lu ChenKey Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, Chengdu, China.
Jing-Wen LinCenter of Infectious Diseases and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.ORCID 0000-0003-3338-8788

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pulmonary manifestation in malaria can be life-threatening. Using a rodent malaria model and comprehensive transcriptomics analyses to illustrate the immune landscape of malaria-associated lung pathology, we identified that IFN-γ signaling in T cells plays an important role in malaria-associated lung pathology. Disruption of IFN-γ signaling in T cells leads to reduced parasite load in the lungs and attenuated lung pathology by enhancing T cell-monocyte interaction. Surprisingly, the stronger interaction leads to an increase in a proinflammatory monocyte subset characterized by CD8 and Ly6C expression, which exhibits prominently elevated phagocytic capacity compared to the CD8

Indexed as

Interferon-gammaMalariaPhagocytosisSignal TransductionT-LymphocytesAnimalsDisease Models, AnimalFemaleGene Expression ProfilingLungMiceMice, Inbred C57BLMonocytesInterferon-gammaCD8+Ly6C+ monocyteCD8+ T celllung pathologymalariaphagocytosisPlasmodiumT cell-monocyte interaction

Identifiers

PMID41810957
PMCPMC13059739

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.