Evidence map›Paper›PMID 41810935›Full record

ArticleAnalytical cellular pathology (Amsterdam)2026

Gliosarcoma: A Reappraisal of Neuroradiological, Surgical, Morphological, and Radiotherapeutic Characteristics of a Cohort From South Italy Single-Center.

Ida Rizzuto, Antonio Ieni, Sarah Caroline Scarcella, Valentina Sciacca, Vincenzo Fiorentino, Claudio Napoli, Maurizio Martini, Antonino Germanò, Francesca Granata, Stefano Pergolizzi and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Analytical cellular pathology (Amsterdam), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ida RizzutoDepartment of Human Pathology in Adult and Developmental Age "Gaetano Barresi", University of Messina, Via Consolare Valeria 1, 98125, Messina, Sicily, Italy, unime.it.
Antonio IeniDepartment of Human Pathology in Adult and Developmental Age "Gaetano Barresi", University of Messina, Via Consolare Valeria 1, 98125, Messina, Sicily, Italy, unime.it.ORCID https://orcid.org/0000-0002-0493-7621
Sarah Caroline ScarcellaDepartment of Biomedical, Dental Science and Morphological and Functional Images, University of Messina, Messina, Sicily, Italy, unime.it.
Valentina SciaccaDepartment of Human Pathology in Adult and Developmental Age "Gaetano Barresi", University of Messina, Via Consolare Valeria 1, 98125, Messina, Sicily, Italy, unime.it.
Vincenzo FiorentinoDepartment of Human Pathology in Adult and Developmental Age "Gaetano Barresi", University of Messina, Via Consolare Valeria 1, 98125, Messina, Sicily, Italy, unime.it.ORCID https://orcid.org/0000-0002-1132-1761
Claudio NapoliDepartment of Human Pathology in Adult and Developmental Age "Gaetano Barresi", University of Messina, Via Consolare Valeria 1, 98125, Messina, Sicily, Italy, unime.it.
Maurizio MartiniDepartment of Human Pathology in Adult and Developmental Age "Gaetano Barresi", University of Messina, Via Consolare Valeria 1, 98125, Messina, Sicily, Italy, unime.it.
Antonino GermanòDepartment of Biomedical, Dental Science and Morphological and Functional Images, University of Messina, Messina, Sicily, Italy, unime.it.
Francesca GranataDepartment of Biomedical, Dental Science and Morphological and Functional Images, University of Messina, Messina, Sicily, Italy, unime.it.
Stefano PergolizziDepartment of Human Pathology in Adult and Developmental Age "Gaetano Barresi", University of Messina, Via Consolare Valeria 1, 98125, Messina, Sicily, Italy, unime.it.
Giovanni TuccariDepartment of Human Pathology in Adult and Developmental Age "Gaetano Barresi", University of Messina, Via Consolare Valeria 1, 98125, Messina, Sicily, Italy, unime.it.ORCID https://orcid.org/0000-0002-1561-4246

Funding

CRUI-CAREUniversita degli Studi di Messina
6 · The paper itself

Abstract

Gliosarcoma (GS) is a rare and aggressive variant of glioblastoma multiforme (GBM), characterized by a biphasic histopathological pattern featuring both glial and mesenchymal components. Accounting for 2% of all GBM cases, this brain tumor is known for its poor prognosis, rapid progression, and resistance to conventional treatments. Despite advances in molecular profiling and multimodal treatment strategies, GS remains a therapeutic challenge due to their highly invasive nature and limited response to standard regimens. The purpose of this study was to characterize the neuroradiological, surgical, clinicopathological, and radiotherapeutic profiles of a cohort of patients affected by GS, including two recurrences of disease.

Indexed as

Brain NeoplasmsGliosarcomaAdultAgedCohort StudiesFemaleHumansItalyMagnetic Resonance ImagingMaleMiddle AgedNeoplasm Recurrence, LocalPrognosiscentral nervous systemgliosarcomaimagingimmunohistochemistryprognosisradiotherapy

Identifiers

PMID41810935
PMCPMC13580779

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.