Evidence map›Paper›PMID 41810927›Full record

ArticleAnalytical cellular pathology (Amsterdam)2026

Regulation of Cell Function and Myeloid-Derived Suppressor Cell Chemotaxis by hsa_circ_0006466-miR-1286-PDGFRA/B Axis in Triple Negative Breast Cancer.

Fengqin Gao, Mingkai Gong, Yufeng Cao, Xiaoyi Liu, Jian Cui, Bing Du, Rongrong Dou, Chuankui Wei, Hongming Song

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Analytical cellular pathology (Amsterdam), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Fengqin GaoBreast Disease Center, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China, qdu.edu.cn.
Mingkai GongBreast Disease Center, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China, qdu.edu.cn.
Yufeng CaoDepartment of Oncology Center 3, Qingdao Hiser Hospital Affiliated of Qingdao University (Qingdao Traditional Chinese Medicine Hospital), Qingdao, Shandong, China.
Xiaoyi LiuBreast Disease Center, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China, qdu.edu.cn.
Jian CuiBreast Disease Center, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China, qdu.edu.cn.
Bing DuQingdao Medical College, Qingdao University, Qingdao, Shandong, China, qdu.edu.cn.
Rongrong DouBreast Disease Center, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China, qdu.edu.cn.
Chuankui WeiDepartment of General Surgery, The Second Affiliated Hospital of Shandong First Medical University, Taian, Shandong, China, natureindex.com.
Hongming SongBreast Disease Center, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China, qdu.edu.cn.ORCID https://orcid.org/0000-0002-1282-6016

Funding

Natural Science Foundation of Qingdao 25-1-1-224-zyyd-jchNatural Science Foundation of Shandong Province ZR2022MH220
6 · The paper itself

Abstract

backgroundCircular RNAs (circRNAs) play critical regulatory roles in diverse biological processes of breast cancer. This study aimed to investigate the circRNAs potentially related to immunity in triple-negative breast cancer (TNBC).

methodsWe identified the dysregulated circRNAs in breast cancer using Gene Expression Omnibus (GEO) datasets. Then, their targeting microRNAs (miRNAs) were searched and overlapped with the miRNAs upstream of immune-associated genes. An immune-related circRNA-miRNA-mRNA network was constructed. Hsa_circ_0006466-miR-1286-PDGFRA/B axis was verified from perspectives of expression levels, binding relationships, cell functions, and regulation on myeloid-derived suppressor cells (MDSCs).

resultsA total of 28 circRNAs were identified to be dysregulated and related to the immune system in TNBC. The immune-related circRNA-miRNA-mRNA network consisted of 28 circRNAs, 106 miRNAs, and 205 mRNAs. Hsa_circ_0006466 and PDGFRA/B mRNA were upregulated in TNBC patients and positively correlated with MDSC levels. miR-1286 was downregulated in TNBC patients and negatively correlated with MDSC levels. Cotransfection experiments, luciferase reporter assay, and RNA pull-down analyses confirmed hsa_circ_0006466-miR-1286-PDGFRA/B axis. Hsa_circ_0006466 inhibited TNBC cell migration/invasion and proliferation via miR-1286-PDGFRA/B. MDSC differentiation from THP-1 and chemotaxis in TNBC cell medium were moderated by hsa_circ_0006466-miR-1286-PDGFRA/B axis.

conclusionsOur study identifies hsa_circ_0006466 as an immune-related circRNA in TNBC, functioning as a ceRNA to sponge miR-1286 and upregulate PDGFRA/B expression, thereby promoting MDSC-mediated immunosuppression and TNBC progression. Targeting this axis may offer a dual therapeutic strategy to suppress TNBC aggressiveness and reverse immune evasion.

Indexed as

ChemotaxisMicroRNAsMyeloid-Derived Suppressor CellsReceptor, Platelet-Derived Growth Factor alphaReceptor, Platelet-Derived Growth Factor betaRNA, CircularTriple Negative Breast NeoplasmsCell Line, TumorCell MovementCell ProliferationFemaleGene Expression Regulation, NeoplasticGene Regulatory NetworksHumansRNA, Competitive EndogenousSignal TransductionMicroRNAsPDGFRB protein, humanReceptor, Platelet-Derived Growth Factor alphaReceptor, Platelet-Derived Growth Factor betaRNA, CircularRNA, Competitive EndogenouscircRNAmiR-1286myeloid-derived suppressor cellPDGFRAPDGFRBtriple negative breast cancer

Identifiers

PMID41810927
PMCPMC13580802

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.