ArticleInvestigative ophthalmology & visual science2026
Common and Distinct Features in Serum Proteomic Profiles in Keratoconus, Post-Laser Vision Correction Ectasia, and Pellucid Marginal Degeneration.
Article in Investigative ophthalmology & visual science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Proteomic Profile Differences in Immune-Related Diseases in Pediatric Patients Under Five Years Old: Asthma and IgE-Dependent Allergies-A Pilot Study.International journal of molecular sciences · 2026Article
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Both intrinsic and extrinsic factors are implicated in keratoconus (KTCN), pellucid marginal degeneration (PMD), and post-laser vision correction (PLVC) ectasia etiology. Serum proteomic profiling was performed to molecularly differentiate the ectasia and to assess systemic components in their pathophysiology. Methods: Serum samples from 93 patients with KTCN, 10 patients with PLVC, 4 patients with PMD, and 44 non-ectatic controls were profiled using matrix-assisted laser desorption ionization-time of flight tandem mass spectrometry (MALDI-TOF/TOF MS/MS). Clinical and environmental variables (e.g. allergy/atopy/asthma and eye rubbing intensity), together with ophthalmologic parameters (K1, K2, Kmax, TCT, and anterior/posterior elevation), were assessed in the principal component analysis (PCA), Weighted Gene Co-expression Network Analysis (WGCNA), linear modeling, and other assessments. Serum m/z features were correlated with RNA-seq data from corneal epithelium (CE) samples of 31 individuals. Results: As findings of the PCA, associations were observed for atopy and/or asthma (estimate = -5.52, P = 0.03), PMD diagnosis (estimate = 8.3, P = 0.04), and age (estimate = -0.14, P = 0.01), with observable trends for KTCN status and intense eye rubbing. Correlations between clinical variables and individual m/z features indicated that posterior elevation, reflecting KTCN severity, was associated with an ATP5B protein-assigned peak (m/z 1921.9655, ρ = -0.31, adjusted P = 0.016). In the integration analyses, correlations between serum peaks and corresponding CE gene expression, including APOH- (ρ = 0.43, P = 0.017) and ALB-assigned peaks (ρ = 0.35-0.42, P < 0.05) were identified. Pairwise eigengene comparisons showed negative correlation between KTCN and non-ectatic controls (Pearson r = -0.89, P = 0.007). Conclusions: The local ocular pathology is reflected in serum proteomic profiles, together with accompanying systemic inflammation and intense eye-rubbing behavior. Common proteomic features of different types of corneal ectasia may reflect overlapping pathophysiological mechanisms.
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