Evidence map›Paper›PMID 41810888›Full record

ReviewJMIR AI2026

Important Ethical, Technical, and Epidemiological Considerations in an AI Tool Production (ETEPAI): Scoping Review.

Boon How Chew, Kee Yuan Ngiam

Abstract readReview
In one paragraph

Review in JMIR AI, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Boon How ChewDepartment of Family Medicine, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.ORCID http://orcid.org/0000-0002-8627-6248
Kee Yuan NgiamDepartment of Biomedical Informatics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.ORCID http://orcid.org/0000-0001-5676-2520

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Artificial intelligence (AI) tools are being developed in a rapidly evolving technology. The convergence of ethical, technical, and research methods' considerations is crucial for multidisciplinary teams aiming to produce effective AI tools. The success of these tools postdeployment hinges on the intricate interplay between the AI system's development on its output through rigorous decision-making processes and stakeholders' capacity to act on the AI's recommendations. Objective: This paper synthesizes ethical, technical, and epidemiological considerations for all involved in artificial intelligence tool production (ETEPAI), based on established guidelines, checklists, and frameworks. Methods: Relevant guidelines, checklists, frameworks, and expert recommendations were systematically identified and synthesized into ETEPAI, an ethical, technical, and epidemiological framework for AI tool development in health care. Results: From 30 reviewed frameworks, ETEPAI integrates critical considerations across 4 stages (design, development, deployment, and postdeployment) and 3 domains (ethics, technical, and epidemiological), providing a compact yet comprehensive guide. It includes probing questions, key indicators, and common pitfalls to support high-quality, ethically sound, and clinically relevant AI tools. ETEPAI aligns with European Union trustworthiness standards and is supported by a research proposal template and supplementary references to aid implementation and adoption. We present probing questions and critical pointers across 4 stages from the design, development, deployment, and postdeployment, highlighting their relevance in health care settings. The designing stage aligns with epidemiologic research methodologies, while the development stage emphasizes transparent project execution. Deployment and postdeployment stages focus on real-world implementation. Additionally included are common pitfalls and challenges to emphasize the importance of due attention to the importance of ETEPAI considerations to avoid serious consequences. Conclusions: Applying ETEPAI ensures comprehensive, complete, compact, and crisp consideration from conception to execution, promoting high-quality, ethically sound, and clinically relevant AI tools. The brevity and conciseness of ETEPAI might be adequate for trained personnel and serve as clear signposts to unprepared stakeholders.

Indexed as

artificial intelligenceclinical decision support systemsepidemiologyethicspractice guidelines

Identifiers

PMID41810888
PMCPMC12977167

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.