Evidence map›Paper›PMID 41810562›Full record

ArticlePsychological medicine2026

Maternal adverse childhood experiences and prenatal stress: Intergenerational transmission and offspring mental health in the ECHO Cohort.

Shaikh I Ahmad, Alexandra D W Sullivan, Marie L Churchill, Rosa M Crum, Amanda N Noroña-Zhou, Nora K Moog, Patricia A Brennan, Emily S Barrett, Rebecca J Schmidt, Claudia Buss and 29 more

Abstract read
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Article in Psychological medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

39 authors.

Shaikh I AhmadDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, USA.ORCID 0000-0001-5662-278X
Alexandra D W SullivanDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, USA.ORCID 0000-0003-4513-9578
Marie L ChurchillDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA.ORCID 0000-0002-3657-8344
Rosa M CrumDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA.
Amanda N Noroña-ZhouDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, USA.
Nora K MoogInstitute of Medical Psychology, Heidelberg University, Heidelberg, Germany.ORCID 0000-0002-7532-7206
Patricia A BrennanDepartment of Psychology, Emory University, Atlanta, USA.ORCID 0000-0003-3742-2891
Emily S BarrettRutgers School of Public Health, Piscataway, USA.
Rebecca J SchmidtDepartment of Public Health Sciences, MIND Institute, University of California Davis School of Medicine, Davis, USA.ORCID 0000-0003-1582-2747
Claudia BussCharité-Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Medical Psychology, Berlin, Germany.
Leslie D LevePrevention Science Institute, University of Oregon, Eugene, USA.ORCID 0000-0003-3061-4524
Michael A CocciaDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, USA.ORCID 0000-0002-6285-4971
Judy L AschnerCenter for Discovery and Innovation, Hackensack Meridian School of Medicine, Nutley, USA.ORCID 0000-0001-8420-7794
Lyndsay A AvalosDivision of Research, Kaiser Permanente Northern California, Pleasanton, USA.
Theresa M BastainDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, USA.
Lisa CroenDivision of Research, Kaiser Permanente Northern California, Pleasanton, USA.
Dana DabeleaLifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora, USA.ORCID 0000-0001-9514-8929
Anne L DunlopDepartment of Gynecology & Obstetrics, Emory University School of Medicine, Atlanta, USA.ORCID 0000-0002-5092-8136
Michelle Bosquet EnlowDepartment of Psychiatry and Behavioral Sciences, Boston Children's Hospital, Boston, USA.ORCID 0000-0003-2598-3894
Assiamira FerraraDivision of Research, Kaiser Permanente Northern California, Pleasanton, USA.
Alison E HipwellDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, USA.
Akram N AlshawabkehDepartment of Civil and Environmental Engineering, College of Engineering, Northeastern University, Boston, USA.ORCID 0000-0001-5243-4087
Kristen LyallAJ Drexel Autism Institute, Drexel University, Philadelphia, USA.
Daphne Koinis-MitchellDepartment of Pediatrics, Rhode Island Hospital, Warren Alpert Medical School at Brown University, Providence, USA.
Thomas G O'ConnorDepartment of Psychiatry, University of Rochester Medical Center, Rochester, USA.ORCID 0000-0002-8590-5057
Emily OkenHarvard Medical School, Harvard Pilgrim Health Care Institute, Boston, USA.ORCID 0000-0003-2513-3339
Hudson P SantosUniversity of Miami School of Nursing and Health Studies, Miami, USA.ORCID 0000-0002-4040-366X
Rosalind J WrightDepartment of Public Health, Icahn School of Medicine at Mount Sinai, New York, USA.
Jessica ArizagaDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, USA.ORCID 0000-0003-1399-6583
Su H ChuChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, USA.ORCID 0000-0002-6345-008X
Heather Derry-VickCenter for Discovery and Innovation, Hackensack Meridian Health, New York, USA.ORCID 0000-0003-0753-0859
Karen M TabbSchool of Social Work, University of Illinois at Urbana-Champaign, Urbana, USA.ORCID 0000-0002-4722-9502
Christine W HockettAvera Research Institute, Sioux Falls, USA.ORCID 0000-0002-1665-6763
Rachel S KellyChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, USA.ORCID 0000-0003-3023-1822
Brooke G McKennaDepartment of Psychology, Emory University, Atlanta, USA.ORCID 0000-0001-9909-1448
John D MeekerDepartment of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, USA.ORCID 0000-0001-8357-5085
Kaja Z LeWinnDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, USA.
Nicole R BushDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, USA.ORCID 0000-0003-0217-9975
ECHO Cohort Consortium

Funding

ENVIRONMENTAL INFLUENCES ON NEURODEVELOPMENTAL OUTCOME IN INFANTS BORN VERY PRETERMUH3OD023347 · OD · WOMEN AND INFANTS HOSPITAL-RHODE ISLAND · PI LESTER, BARRY M., MARSIT, CARMEN JOSEPH · 2018 to 2022
$18.4M
BREAKING THE CYCLE OF INTERGENERATIONAL DISADVANTAGE: NEURODEVELOPMENT AMONG PUERTO RICAN CHILDREN.UH3OD023328 · OD · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI CANINO, GLORISA J, DUARTE, CRISTIANE S. · 2018 to 2022
$18.3M
Sleep and Circadian Dysfunction, Brain and Neurobehavioral Development in AutismP50HD103538 · NICHD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI Stewart H Mostofsky · 2020 to 2026
$9.9M
The Impact of the Intrauterine and Early Childhood Environments on Neurocognitive and Metabolic Development in African American Youth: Focus on the Gut-Brain AxisUH3OD023318 · OD · EMORY UNIVERSITY · PI PATRICIA A BRENNAN, ANNE Lang DUNLOP · 2018 to 2026
$9.0M
CLINICAL SERVICES RESEARCH TRAINING PROGRAMT32MH018261 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Kaja Zabrina LeWinn, Rachel L. Loewy · 1985 to 2026
$7.0M
Miami-ECHO: A Diverse Cohort of Mothers, Children and Fathers in Miami-Dade CountyUG3OD035542 · OD · UNIVERSITY OF MIAMI CORAL GABLES · PI PAIDAS, MICHAEL JOHN, SANTOS, HUDSON · 2023 to 2024
$6.8M
New Jersey ECHOUG3OD035527 · OD · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI BARRETT, EMILY S, BLASER, MARTIN J · 2023 to 2024
$3.2M
Prenatal Environment And Child Health (PEACH) in ECHOUG3OD035550 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SCHMIDT, REBECCA JEAN · 2023 to 2024
$3.2M
NICHD NIH HHS P50 HD103538NIH Office of the Director G3/UH3OD023289NIH Office of the Director U2COD023375, U24OD023382, U24OD023319, U24OD035523, ES0266542, U24ES026539, U2CES026533, U2CES026542, U2CES030859, U2CES030857, U2CES026555, U2CES026561, U2CES030851NIH Office of the Director UG3OD035527NIH Office of the Director UG3OD035536, UG3OD035544NIH Office of the Director UG3OD035540, UG3OD035543, UG3OD035537, UG3OD035529NIH Office of the Director UG3OD035542NIH Office of the Director UG3OD035550NIH Office of the Director UG3/UH3OD023248 and UG3OD035526NIH Office of the Director UG3/UH3OD023251NIH Office of the Director UG3/UH3OD023279NIH Office of the Director UG3/UH3OD023282, UH3OD023287, UG3/UH3OD023365, UG3/UH3OD023244, UG3/UH3OD023275NIH Office of the Director UG3/UH3OD023313NIH Office of the Director UG3/UH3OD023342NIH Office of the Director UG3/UH3OD023344, UH3OD023268, UG3/UH3OD023288, UG3/UH3OD023342NIH Office of the Director UH3OD023271 and UG3OD035528NIH Office of the Director UH3OD023286 and UG3OD035533, UG3/UH3OD023348, UG3/UH3OD023285, UG3/UH3OD023290, UG3/UH3OD023272, UG3/UH3OD023249, UG3/UH3OD023305, UG3/UH3OD023337, UG3OD035508, UG3OD035509, UG3OD035513 and UG3OD035532, UG3OD035516 and UG3OD035517, UG3OD035518, UG3OD03551NIH Office of the Director UH3OD023318NIH Office of the Director UH3OD023320 and UG3OD035546NIH Office of the Director UH3OD023328NIH Office of the Director UH3OD023332, UG3/UH3OD023253NIH Office of the Director UH3OD023347NIMH NIH HHS T32MH018261
6 · The paper itself

Abstract

backgroundThe rising global prevalence of pediatric mental health problems requires the identification of preventable factors underlying their development. This study assessed whether maternal adverse childhood experiences (ACEs) and pregnancy stress were intergenerationally associated with offspring mental health.

methodsThis study used data from 34 sites in the nationwide Environmental Influences on Child Health Outcomes Cohort. Eligible parent-child dyads (child age: 1.5-18 years) provided data on at least one measure of maternal stress and at least one measure of child mental health. Study aims were evaluated using regression analyses, including interaction tests to determine potential effect modifiers.

resultsParticipants were organized into three subsamples with data on (1) maternal ACEs (

conclusionsMaternal exposure to ACEs and pregnancy stress were associated with the development of child mental health problems. These findings highlight the need for policies and interventions that mitigate exposure to adversity and protect pregnant individuals and their children from the intergenerational transmission of mental health problems.

Indexed as

Adverse Childhood ExperiencesMental DisordersPrenatal Exposure Delayed EffectsStress, PsychologicalAdolescentAdultChildChild, PreschoolCohort StudiesFemaleHumansInfantMalePregnancySubjective Stressadverse childhood experienceschild mental healthchild psychopathologyintergenerational transmissionpregnancy stress

Identifiers

PMID41810562
PMCPMC13040406

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