Evidence map›Paper›PMID 41810470›Full record

ArticleAsian journal of pharmaceutical sciences2026

Inhalable stem cell-derived artificial nanovesicles for targeted siRNA delivery to effectively alleviate asthma symptoms.

Shihan Chen, Ruyi Lin, Yuhuan Kong, Hao Sun, Jiawen Wang, Jinsong Zhang, Yanshuang Huang, Honghui Wu, Donghang Xu, Jianqing Gao and 1 more

Abstract read
In one paragraph

Article in Asian journal of pharmaceutical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shihan ChenSchool of Pharmacy, Zhejiang University, Hangzhou 310058, China.
Ruyi LinSchool of Pharmacy, Zhejiang University, Hangzhou 310058, China.
Yuhuan KongSchool of Pharmacy, Zhejiang University, Hangzhou 310058, China.
Hao SunSchool of Pharmacy, Zhejiang University, Hangzhou 310058, China.
Jiawen WangSchool of Pharmacy, Zhejiang University, Hangzhou 310058, China.
Jinsong ZhangSchool of Pharmacy, Zhejiang University, Hangzhou 310058, China.
Yanshuang HuangSchool of Pharmacy, Zhejiang University, Hangzhou 310058, China.
Honghui WuSchool of Pharmacy, Zhejiang University, Hangzhou 310058, China.
Donghang XuDepartment of Pharmacy, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
Jianqing GaoSchool of Pharmacy, Zhejiang University, Hangzhou 310058, China.
Tianyuan ZhangSchool of Pharmacy, Zhejiang University, Hangzhou 310058, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Asthma, one of the most prevalent chronic inflammatory diseases, remains challenging to manage effectively. Current therapies commonly alleviate symptoms through broad immunosuppression and bronchodilation but fail to target disease-specific molecular pathways. Genetic intervention using small interfering RNA (siRNA) has emerged as a promising strategy for asthma therapy. However, its success is largely hindered by the lack of an efficient delivery approach targeting airway epithelial cells (AECs). Here, we developed a novel inhalable siRNA delivery system based on artificially prepared nanovesicles through designed extrusion processes of mesenchymal stem cells. To enable an effective inhalation delivery of siRNA

Indexed as

AsthmaInhalationMesenchymal stem cellsNanovesiclessiRNA delivery

Identifiers

PMID41810470
PMCPMC12906011

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.