Evidence map›Paper›PMID 41810447›Full record

ReviewWorld journal of gastroenterology2026

Small animal

Klaudija Bickaite-Bausiene, Mindaugas Kvietkauskas, Bettina Leber, Bernardas Bausys, Dagmar Brislinger, Kestutis Strupas, Philipp Stiegler

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Klaudija Bickaite-BausieneDivision of General, Visceral and Transplant Surgery, Department of Surgery, Medical University of Graz, Graz 8036, Steiermark, Austria.
Mindaugas KvietkauskasClinic of Gastroenterology, Nephro-Urology and Surgery, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius 03101, Lithuania.
Bettina LeberDivision of General, Visceral and Transplant Surgery, Department of Surgery, Medical University of Graz, Graz 8036, Steiermark, Austria.
Bernardas BausysFaculty of Medicine, Vilnius University, Vilnius 03101, Lithuania.
Dagmar BrislingerDepartment of Cell Biology, Histology and Embryology, Medical University of Graz, Graz 8010, Steiermark, Austria.
Kestutis StrupasClinic of Gastroenterology, Nephro-Urology and Surgery, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius 03101, Lithuania.
Philipp StieglerDivision of General, Visceral and Transplant Surgery, Department of Surgery, Medical University of Graz, Graz 8036, Steiermark, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLiver transplantation is the only treatment for acute and chronic liver failure, but the global organ shortage has increased reliance on extended criteria donor livers, which are more susceptible to ischemia-reperfusion injury. While static cold storage is standard, these grafts often require improved preservation strategies.

aimTo summarize the current state of small animal liver machine perfusion (MP), highlight variability in protocols, and emphasize the need for standardization to guide future research.

methodsA comprehensive literature search of PubMed was conducted to identify studies on small animal (rat and mouse)

resultsSmall animal liver MP provides a cost-effective model to explore dynamic preservation strategies. Rat perfusion studies face challenges including dual-vessel perfusion, maintaining physiological perfusate volumes, and lack of standardized protocols. Open- and closed-circuit setups have distinct advantages and limitations, and experimental designs vary widely across studies.

conclusionThis review illustrates the wide variability in small animal liver MP protocols and underscores the urgent need for standardization. Addressing these inconsistencies will enhance reproducibility, facilitate comparison across studies, and support the development of optimized liver preservation strategies.

Indexed as

LiverLiver TransplantationOrgan PreservationPerfusionReperfusion InjuryAnimalsHumansMiceModels, AnimalOrgan Preservation SolutionsRatsReproducibility of ResultsOrgan Preservation SolutionsEx vivo liver machine perfusionLiver transplantLiver transplantationMachine perfusionSmall animal machine perfusion

Identifiers

PMID41810447
PMCPMC12968579

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.