Evidence map›Paper›PMID 41810437›Full record

ArticleWorld journal of gastroenterology2026

Establishing an esophago-pleural fistula disease model in rabbits with a magnetic compression technique.

Qing He, Xiang-Yu Chen, Qin Xiang, Chang-Hao Huang, Zhi-Wei Wu

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Article in World journal of gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Qing HeThe Hunan Provincial Key Lab of Precision Diagnosis and Treatment for Gastrointestinal Tumor, Xiangya Hospital of Central South University, Changsha 410000, Hunan Province, China.
Xiang-Yu ChenDepartment of Laboratory Medicine, The Third Xiangya Hospital of Central South University, Changsha 410000, Hunan Province, China.
Qin XiangHunan Provincial University Key Laboratory of the Fundamental and Clinical Research on Neurodegenerative Diseases, Changsha Medical University, Changsha 410000, Hunan Province, China.
Chang-Hao HuangThe Hunan Provincial Key Lab of Precision Diagnosis and Treatment for Gastrointestinal Tumor, Xiangya Hospital of Central South University, Changsha 410000, Hunan Province, China.
Zhi-Wei WuThe Hunan Provincial Key Lab of Precision Diagnosis and Treatment for Gastrointestinal Tumor, Xiangya Hospital of Central South University, Changsha 410000, Hunan Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEsophageal pleural fistula (EPF) primarily arises as a complication of esophageal surgery, malignant tumors, or trauma. The high mortality rate associated with EPF underscores the critical need for early diagnosis and aggressive treatment, which often involves a multidisciplinary approach including thoracic drainage, broad-spectrum antibiotics, nutritional support, and often surgical or endoscopic intervention. Despite its clinical severity, a corresponding animal disease model for mechanistic and therapeutic research remains unavailable.

aimTo establish a stable and reproducible EPF animal model using magnetic compression technology (MCT).

methodsEPF modeling surgery was successfully performed on 20 New Zealand white rabbits (weight: 2-3 kg) with our self-developed MCT device. Postoperatively, radiographic confirmation of magnet positioning was conducted within 24 hours. Fistula tract tissue samples were subjected to hematoxylin-eosin and Masson's trichrome histochemical staining. Pathological specimens were intentionally withheld from a subset of rabbits (

resultsThe rabbit model of EPF was successfully established. The average surgical time was 26.6 ± 4 minutes. Magnets were spontaneously excreted at 7.0 ± 0.7 days postoperatively (

conclusionThe magnetic compression-derived rabbit EPF model exhibits high establishment success and prolonged viability, enabling robust pathophysiological research.

Indexed as

Disease Models, AnimalEsophageal FistulaMagneticsPleural DiseasesAnimalsMagnetsMaleRabbitsReproducibility of ResultsTime Factors3D printingDigestive tract fistulaDisease modelEsophago-pleural fistulaMagnetic compression techniqueRabbit model

Identifiers

PMID41810437
PMCPMC12968578

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