Evidence map›Paper›PMID 41810417›Full record

ArticleInternet interventions2026

Not just spontaneous remission: Time-dependent and independent effects in pre-intervention symptom reduction.

Vilgot Huhn, Nils Hentati Isacsson, Marie Bendix, Martin Kraepelien, Hanna Sahlin, Viktor Kaldo, Erik Forsell

Abstract read
In one paragraph

Article in Internet interventions, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Vilgot HuhnCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm Health Care Services, Region Stockholm, Sweden.
Nils Hentati IsacssonCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm Health Care Services, Region Stockholm, Sweden.
Marie BendixCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm Health Care Services, Region Stockholm, Sweden.
Martin KraepelienCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm Health Care Services, Region Stockholm, Sweden.
Hanna SahlinCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm Health Care Services, Region Stockholm, Sweden.
Viktor KaldoCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm Health Care Services, Region Stockholm, Sweden.
Erik ForsellCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm Health Care Services, Region Stockholm, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Psychological symptoms tend to change over time, even in the absence of clinical intervention. For example, self-ratings are often higher at screening compared to start of treatment. A plausible hypothesis is that this is due to patients' self-referring when their gradually fluctuating symptoms are worse than usual. That hypothesis predicts that patients that wait longer will have had longer time to return to their average symptom level. On the other hand, other processes related to measurement reactivity, contact with a clinician, or regression towards the mean, do not predict a time-dependent relationship. Our aim was to estimate the extent of this hypothesized symptom reduction in depression, social anxiety disorder, panic disorder, health anxiety and insomnia (both total reduction and the relationship with time). The sample included adults (

Indexed as

DepressionHealth anxietyInsomniaMeasurement reactivityNatural coursePanic disorderRegression towards the meanSocial anxiety disorderSymptom fluctuations

Identifiers

PMID41810417
PMCPMC12969135

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.