Evidence map›Paper›PMID 41810385›Full record

ArticleThe Lancet regional health. Western Pacific2026

Genetic risk loci for Parkinson's disease and dementia in a large-scale population-based Taiwanese cohort (TPMI).

Chin-Hsien Lin, Chien-Ching Chang, Hung-Hsin Chen, Wan-Jia Lin, Chia-Lang Hsu, Rung-Juen Lin, Yi-Jen Guo, Ting-Chun Fang, Shinn-Zong Lin, Chih-Yang Huang and 17 more

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In one paragraph

Article in The Lancet regional health. Western Pacific, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Chin-Hsien LinDepartment of Neurology, National Taiwan University Hospital, Taipei, 100225, Taiwan.
Chien-Ching ChangInstitute of Biomedical Sciences, Academia Sinica, Taipei, 11529, Taiwan.
Hung-Hsin ChenInstitute of Biomedical Sciences, Academia Sinica, Taipei, 11529, Taiwan.
Wan-Jia LinInstitute of Biomedical Sciences, Academia Sinica, Taipei, 11529, Taiwan.
Chia-Lang HsuDepartment of Medical Research, National Taiwan University Hospital, Taipei, 10025, Taiwan.
Rung-Juen LinDepartment of Neurology, National Taiwan University Hospital, Taipei, 100225, Taiwan.
Yi-Jen GuoDepartment of Neurological Institute, Taichung Veterans General Hospital, Taichung, 407005, Taiwan.
Ting-Chun FangDepartment of Neurological Institute, Taichung Veterans General Hospital, Taichung, 407005, Taiwan.
Shinn-Zong LinBioinnovation Center, Buddhist Tzu Chi Medical Foundation, Hualien, 970473, Taiwan.
Chih-Yang HuangCardiovascular and Mitochondria Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, 970473, Taiwan.
Shuu-Jiun WangDepartment of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, 11217, Taiwan.
Jen-Fan HangDepartment of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, 11217, Taiwan.
Sun-Wung HsiehDepartment of Public Health, Kaohsiung Medical University, Kaohsiung, 807378, Taiwan.
Mei-Chuan ChouDepartment of Neurology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, 807378, Taiwan.
Tu-Hsueh YehDepartment of Neurology, Taipei Medical University Hospital, Taipei, 110301, Taiwan.
Chaur-Jong HuDepartment of Neurology, College of Medicine, Taipei Medical University, Taipei, 110301, Taiwan.
Fu-Chi YangDepartment of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei, 114202, Taiwan.
Hsin-An ChangDepartment of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, 114202, Taiwan.
Tsong-Hai LeeDepartment of Neurology, Chang Gung Memorial Hospital and College of Medicine, Chang Gung University, Taoyuan, 33302, Taiwan.
Meng-Han TsaiDepartment of Neurology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, 83301, Taiwan.
Ming-Che KuoDepartment of Medicine, National Taiwan University Cancer Center, Taipei, 11008, Taiwan.
Jyh-Ming LiouDepartment of Medicine, National Taiwan University Cancer Center, Taipei, 11008, Taiwan.
Ming-Shiang WuDepartment of Gastroenterology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, 10025, Taiwan.
Kye Won ParkDepartment of Neurology, Gangneung Asan Hospital University of Ulsan College of Medicine, Gangneung, South Korea.
Sun Ju ChungDepartment of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Eng-King TanDepartment of Neurology, Singapore General Hospital, Singapore, 169608, Singapore.
Cathy Shen-Jang FannInstitute of Biomedical Sciences, Academia Sinica, Taipei, 11529, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The genetic architecture of Parkinson's disease (PD) and progression to PD dementia (PDD) remains incompletely characterized in Asians. Here, we investigated genetic risk factors for PD and PDD in Taiwanese individuals from the Taiwan Precision Medicine Initiative (TPMI), the largest non-European cohort integrating genetic and electronic medical record data. Methods: We conducted a two-stage population-based case-control genome-wide association study (GWAS) with a 1:10 case-to-control ratio. Results were meta-analyzed with an independent Asian GWAS. We further constructed a polygenic risk score (PRS) to distinguish PD cases from controls. PDD risk was assessed using logistic regression and Cox models, with replication in an independent cohort that underwent whole-genome sequencing (WGS). Findings: Among 463,447 TPMI participants, 4381 PD patients and 43,810 controls were analysed. We confirmed established PD loci at Interpretation: Our findings highlight both shared and ethnicity-specific PD risk loci and identify Funding: Academia Sinica and National Development Fund.

Indexed as

DementiaGenome-wide association studyParkinson's disease

Identifiers

PMID41810385
PMCPMC12969348

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.