ArticleInternational journal of applied & basic medical research
Fluoride Exposure as a Possible Environmental Modifier of Idiopathic Parkinson's Disease: Insights from a Rural North Indian Cohort.
Article in International journal of applied & basic medical research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: Environmental factors may influence Parkinson's disease (PD) severity and progression. This study investigated the impact of chronic fluoride exposure on the clinical characteristics and short-term progression of idiopathic PD (IPD) in a rural North Indian cohort. Materials and Methods: A prospective observational study enrolled 52 IPD patients from fluoride-endemic ( Results: At baseline, patients from fluoride-endemic areas had higher total MDS-UPDRS scores (68.2 ± 15.4 vs. 58.1 ± 14.3, Conclusion: Chronic fluoride exposure is associated with increased disease severity and may accelerate short-term progression in IPD. These findings highlight the potential role of environmental neurotoxins as modifiable factors influencing PD outcomes and underscore the need for targeted public health interventions in fluoride-endemic regions.
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