ArticleNeuropsychiatric disease and treatment2026
Intestinal Flora Reconfiguration via Electroacupuncture: A Strategy to Counteract Depressive-Like Symptoms in Rats.
Article in Neuropsychiatric disease and treatment, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Does the Microbiota-Gut-Brain Axis Mediate the Antidepressant Effects of Acupuncture? A Structured Review of Preclinical and Clinical Evidence.Neuropsychiatric disease and treatment · 2026Review
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Authors and funding
7 authors.
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Abstract
Background: Depression is a global health concern, and acupuncture has emerged as an effective treatment. The role of intestinal microbiota in depression remains unclear. This study, utilizing 16S rRNA high-throughput sequencing, aimed to explore the relationship between electroacupuncture (EA) and depressive behavior by examining changes in the intestinal microbiota. Materials and Methods: Forty-eight male Sprague-Dawley rats were utilized, with 13 assigned to the normal control (NC) group. The remaining rats underwent a 28-day depression modeling process, and those exhibiting depressive symptoms were randomly divided into chronic unpredictable mild stress (CUMS) and EA groups. The EA group received 14 days of treatment. Behavioral analyses were conducted on rats from the NC, CUMS, and EA groups to assess EA's effectiveness. Additionally, 16S rRNA sequencing was performed on randomly selected rats from each group. Results: By examining the behavior of 39 rats and the intestinal microbiota of 18 rats, we found that EA may alter the composition of the intestinal microbiota community structure in CUMS rats, particularly modulating the abundance of Conclusion: The potential antidepressant impact of electroacupuncture (EA) might be linked to the modulation of
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