Evidence map›Paper›PMID 41810237›Full record

ArticleFrontiers in medicine2026

Case Report: Immune reconstitution-related neurological deterioration in advanced HIV infection with multiple opportunistic infections: a diagnostic challenge.

Jesús Endara-Mina, Cristopher-Josué Escudero, Victor Samaniego, Karla Fuentes, William Tapia, Cesar Intriago

Abstract readCase Reports
In one paragraph

Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jesús Endara-MinaFacultad de Ciencias Jurídicas y Políticas, Universidad Técnica Particular de Loja (UTPL), Loja, Ecuador.
Cristopher-Josué EscuderoFacultad de Ciencias Médicas, Universidad Central del Ecuador (UCE), Quito, Ecuador.
Victor SamaniegoFacultad de Ciencias Médicas, Universidad Central del Ecuador (UCE), Quito, Ecuador.
Karla FuentesFacultad de Ciencias de la Salud Eugenio Espejo, Universidad Técnica Equinoccial (UTE), Quito, Ecuador.
William TapiaServicio de Medicina Interna, Hospital de Especialidades Eugenio Espejo, Quito, Ecuador.
Cesar IntriagoFacultad de Ciencias Médicas, Universidad Central del Ecuador (UCE), Quito, Ecuador.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immune reconstitution inflammatory syndrome (IRIS) is a serious complication following antiretroviral therapy (ART) initiation in patients with advanced HIV infection, particularly when the central nervous system is involved and multiple opportunistic infections coexist. We report the case of a 26-year-old man with newly diagnosed advanced HIV infection who developed rapid neurological deterioration shortly after ART initiation during hospitalization. Neuroimaging revealed a necrotic central nervous system mass lesion with extensive edema and mass effect. Serological testing demonstrated prior exposure to

Indexed as

AIDSantiretroviral agentsHIVMycobacterium tuberculosissyphilistoxoplasmosis

Identifiers

PMID41810237
PMCPMC12968018

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.