ArticleSmall science2026
Systematic Evaluation of Physicochemical Properties of PEGylated Gold Nanorods Reveals Cell-Specific Uptake Determinants in Human Immune Cell Subsets.
Article in Small science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Gold decorated bismuth sulfide nanorods for enhanced computed tomography imaging with in vitro and in vivo validation.Discover nano · 2026Article
- Systematic Evaluation of Physicochemical Properties of PEGylated Gold Nanorods Reveals Cell-Specific Uptake Determinants in Human Immune Cell Subsets.Small science · 2026Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gold nanorods (AuNR) are multifunctional transducers applied in heat-ablating cancer therapy, bio-imaging, and controlled drug release. Despite extensive studies of AuNR interactions with cancer cells, the AuNR characteristics that determine their interaction with primary human immune subsets remain poorly characterized. Here, we investigated the effect of AuNR physico-chemical properties on the binding, uptake, and cell death responses by human T-lymphocytes and polymorphonuclear neutrophils (PMNs). We demonstrate that antibody targeting with α-CD3-AuNR conjugates results in selective binding of AuNR to T-lymphocytes. Photothermal therapy (PTT) using these AuNR triggered apoptotic pathways and evoked selective cell death in T-lymphocytes. In contrast, PMN exhibited nonspecific target-independent uptake, consistent with their inherent phagocytic activity. We evaluated the AuNR size, PEG molecular weight, and surface charge (zeta potential,
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