ArticlePhysics and imaging in radiation oncology2026
Reduction of organ of interest dose in proton therapy for oesophageal cancer through optimized setup robustness settings and online adaptation.
Article in Physics and imaging in radiation oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and purpose: Oesophageal radiotherapy may cause side effects due to high organs of interest (OOIs) doses. While proton therapy (PT) reduces OOI dose compared to photon therapy, setup robustness settings used may limit OOI sparing. This study assessed how optimizing robustness settings for adequate target coverage affected OOI dose, and evaluated the potential of online adaptive PT (OAPT). Materials and methods: Twenty oesophageal cancer patients treated with intensity-modulated PT were analysed. Plans with 8 (clinical standard), 7, 6 and 5 mm setup robustness settings were generated on the planning 4D-CT (pCT) and robustly evaluated on weekly repeat 4D-CTs (rCTs). OAPT plans with individualized robustness settings were optimized and robustly evaluated on rCTs. Clinical target volume (CTV) V Results: A 5 mm setup robustness setting maintained CTV V Conclusions: Reducing setup robustness settings to 5 mm was feasible for most patients and reduced OOI dose. Large anatomical changes required plan adaptation. OAPT allowed further OOI dose reductions while preserving acceptable target coverage.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.