Evidence map›Paper›PMID 41810037›Full record

ArticlePhysics and imaging in radiation oncology2026

Multicentre dosimetry audit in the European randomized phase III study of neoadjuvant chemoradiotherapy using proton versus photon radiotherapy in locally advanced oesophageal cancer.

Mai L Ehmsen, Camilla S Byskov, Hanna R Mortensen, Rebecca Bütof, Richard Canters, Gilles Defraene, Karin Haustermans, Maria Fuglsang Jensen, Arturs Meijers, Christina T Muijs and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physics and imaging in radiation oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Mai L EhmsenDanish Centre for Particle Therapy, Aarhus University Hospital, Aarhus, Denmark.
Camilla S ByskovDepartment of Oncology, Aarhus University Hospital, Aarhus, Denmark.
Hanna R MortensenDanish Centre for Particle Therapy, Aarhus University Hospital, Aarhus, Denmark.
Rebecca BütofDepartment of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany.
Richard CantersDepartment of Radiation Oncology (Maastro), GROW School for Oncology and Reproduction, Maastricht University Medical Centre, Maastricht, Netherlands.
Gilles DefraeneKU Leuven, Department of Oncology, Laboratory of Experimental Radiotherapy, Leuven, Belgium.
Karin HaustermansKU Leuven, Department of Oncology, Laboratory of Experimental Radiotherapy, Leuven, Belgium.
Maria Fuglsang JensenDanish Centre for Particle Therapy, Aarhus University Hospital, Aarhus, Denmark.
Arturs MeijersCenter for Proton Therapy, Paul Scherrer Institut, Villigen, Switzerland.
Christina T MuijsDepartment of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands (the).
Ditte S MøllerDepartment of Oncology, Aarhus University Hospital, Aarhus, Denmark.
Marianne NordsmarkDepartment of Oncology, Aarhus University Hospital, Aarhus, Denmark.
Pieter PopulaireKU Leuven, Department of Oncology, Laboratory of Experimental Radiotherapy, Leuven, Belgium.
Gloria Vilches-FreixasDepartment of Radiation Oncology (Maastro), GROW School for Oncology and Reproduction, Maastricht University Medical Centre, Maastricht, Netherlands.
Lars NyvangDepartment of Oncology, Aarhus University Hospital, Aarhus, Denmark.
Liliana StolarczykDanish Centre for Particle Therapy, Aarhus University Hospital, Aarhus, Denmark.
Sebastian MakockiDepartment of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany.
Sara BroggiIRCCS Scientific Institute San Raffaele, San Raffaele, Milano, Italy.
Francesco FracchiollaUO Fisica Sanitaria, APSS, Trento, Italy.
Andrea MartignanoUO Fisica Sanitaria, APSS, Trento, Italy.
Kenneth PoelsKU Leuven, Department of Oncology, Laboratory of Experimental Radiotherapy, Leuven, Belgium.
Séverine RossommeIon Beam Applications (IBA), Dosimetry Business Unit, Louvain-la-Neuve, Belgium.
Stefan VasiliniucIBA Dosimetry, SSDL Laboratory, Schwarzenbruck, Germany.
Lone HoffmannDepartment of Oncology, Aarhus University Hospital, Aarhus, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study presents the results of a multicentre external dosimetry audit conducted as part of the PROTECT trial, involving nine European radiotherapy centres delivering proton and photon treatments. A dosimetry equipment vendor performed beam output audits at participating sites, verifying the absorbed dose-to-water measurements. Measurements used reference conditions based on the IAEA TRS-398, with ionization chambers traceable to primary standards. The audit compared local centre measurements to independent assessments, finding all within the acceptable 3% agreement threshold. The study is part of the successful implementation of a comprehensive, multicentre QA programme in the PROTECT trial.

Indexed as

Clinical trialDosimetry auditOesophageal cancerRadiotherapy quality assurance

Identifiers

PMID41810037
PMCPMC12969141

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.