Evidence map›Paper›PMID 41810017›Full record

ArticleBioactive materials2026

Dual-function oral nanotherapeutic mitigates sepsis-like multi-organ failure by targeting inflammatory and fibrotic pathways.

James Asenso, Neha Choudhury, Raghu Ganugula, Tyler Posey, Meenakshi Arora, M N V Ravi Kumar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

James AsensoThe Center for Convergent Bioscience and Medicine (CCBM), The University of Alabama, Tuscaloosa, AL, 35401, United States.
Neha ChoudhuryThe Center for Convergent Bioscience and Medicine (CCBM), The University of Alabama, Tuscaloosa, AL, 35401, United States.
Raghu GanugulaThe Center for Convergent Bioscience and Medicine (CCBM), The University of Alabama, Tuscaloosa, AL, 35401, United States.
Tyler PoseyThe Center for Convergent Bioscience and Medicine (CCBM), The University of Alabama, Tuscaloosa, AL, 35401, United States.
Meenakshi AroraThe Center for Convergent Bioscience and Medicine (CCBM), The University of Alabama, Tuscaloosa, AL, 35401, United States.
M N V Ravi KumarThe Center for Convergent Bioscience and Medicine (CCBM), The University of Alabama, Tuscaloosa, AL, 35401, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sepsis, a life-threatening condition, often leads to multi-organ failure and has limited treatment options. We developed a novel dual-function nanoparticle, P2Ns-NAR(NAR), which utilizes naringenin (NAR) as both a targeting ligand for gut folate receptors and an encapsulated therapeutic agent to overcome its poor oral bioavailability. Here, we investigated the efficacy of this oral formulation in a mouse model of lipopolysaccharide-induced sepsis. We observed a significant reduction in the mRNA expression of pro-inflammatory (

Indexed as

ImmunomodulationMulti-organ failureNaringeninOral nanoparticleSepsis

Identifiers

PMID41810017
PMCPMC12969341

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.