ArticleInfection and drug resistance2026
Targeted Next-Generation Sequencing Reveals Distinct Pathogen Profiles in Community-Acquired Pneumonia Across Age and Disease Severity.
Article in Infection and drug resistance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Community-acquired pneumonia (CAP) represents a substantial global health burden; however, the characteristics of its etiological spectrum remain incompletely defined. Targeted next-generation sequencing (tNGS) has significantly advanced the understanding of the etiological spectrum. This study aimed to investigate the pathogen characteristics in CAP patients across different age groups and severity levels based on tNGS results. Methods: We retrospectively analyzed the etiological test results of 272 hospitalized CAP patients at the First Hospital of Shanxi Medical University (Taiyuan, China) from 2021 to 2024. Patients were stratified by age and Pneumonia Severity Index (PSI) score, and their clinical characteristics, etiological spectrum, and infection patterns were systematically evaluated. Results: Among the 145 patients included in the final analysis, 34.48% had simple infections, while 65.52% had multiple infections. Elderly patients (≥80 years) exhibited the highest proportion of mixed infections (81.82%), with the detection rates of viruses and fungi-such as Conclusion: The etiological spectrum of CAP exhibits significant differences across different age groups and disease severity levels. Therefore, stratified diagnosis and therapeutic strategies should be developed based on age and disease severity to optimize prognosis and reduce the misuse of antibiotics.
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