ArticleERJ open research2026
Increased alveolar tissue destruction in a sub-group of COPD patients with increased alveolar septal eosinophil counts.
Article in ERJ open research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
Background: Higher blood eosinophil counts are associated with greater lung function decline in patients with COPD, and a relationship between higher sputum eosinophil counts and greater emphysema has been reported. The aim of the current study was to investigate a role for eosinophils in alveolar septal damage, which may contribute to emphysema and lung function decline in COPD patients. Methods: We quantified Luna positive alveolar septal eosinophil counts (ASEC) in peripheral lung tissue blocks from 48 COPD patients Results: The numbers of ASEC were greater in COPD compared to controls (p≤0.02), and there was a significant correlation between ASEC and alveolar septal damage in a subgroup of COPD patients (rho=0.4, p=0.03). Conclusion: This association suggests a role for eosinophils in the pathogenesis of emphysema in a subset of COPD.
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