Evidence map›Paper›PMID 41809846›Full record

ArticleAdvanced biomedical research2026

Ameliorating Effect of

Merat Mahmoodi, Abdollah Jafarzadeh, Azita Aghaei, Mahnaz Ramezani, Nahid Zainodini, Farnaz Sedghy, Fatemeh Pouya

Abstract read
In one paragraph

Article in Advanced biomedical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Merat MahmoodiDepartment of Immunology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Abdollah JafarzadehDepartment of Immunology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Azita AghaeiPharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran.
Mahnaz RamezaniImmunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Nahid ZainodiniImmunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Farnaz SedghyDepartment of Immunology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Fatemeh PouyaDepartment of Anatomical Sciences, Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Migration of autoreactive T cells into the brain and production of inflammatory cytokines play an undeniable role in the neuronal damage in multiple sclerosis (MS), and its animal model, experimental autoimmune encephalomyelitis (EAE). We investigated the immunomodulatory properties of Materials and Methods: EAE was induced in C57BL/6 mice using the MOG35-55 peptide. Mice were divided into control and lavender-treated groups, receiving phosphate-buffered saline or lavender extract (50 or 100 mg/kg), respectively. Clinical symptoms and body weight were recorded throughout the study, and leukocyte infiltration in brain tissues was evaluated postmortem. Lymphocyte proliferation and cytokine production were assessed using MTT and ELISA assays. Results: Lavender-treated mice showed a considerable amelioration in clinical symptoms and weight loss ( Conclusions: Our results cleared the immunomodulatory effects of lavender in the EAE model. Thus, this herb could be a new candidate for the reduction of damage induced by dysregulation of the immune system in MS and similar autoimmune situations.

Indexed as

C57BL/6 miceexperimental autoimmune encephalomyelitisIL-10IL-17Lavandula angustifoliaTGF-β

Identifiers

PMID41809846
PMCPMC12970768

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.