Evidence map›Paper›PMID 41809831›Full record

ArticleFrontiers in oncology2026

Association of regional specificity of blood-brain barrier permeability with pathological subtypes in cerebral white matter of patients with non-brain metastatic lung cancer.

Haotian Wang, Jian Zeng, Zhengzhen Li, Yonglong Li, Yi Wang, Xiufu Zhang, Jun Zhou, Hongying Liu, Chunrong Wu, Ruipeng Liang

Abstract read
In one paragraph

Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

10 authors.

Haotian Wang *Department of Radiology, Chongqing University Jiangjin Hospital, Chongqing, China.
Jian Zeng *Department of Radiology, Chongqing University Jiangjin Hospital, Chongqing, China.
Zhengzhen Li *Department of Radiology, Chongqing University Jiangjin Hospital, Chongqing, China.
Yonglong LiDepartment of Radiology, Chongqing University Jiangjin Hospital, Chongqing, China.
Yi WangDepartment of Radiology, Chongqing University Jiangjin Hospital, Chongqing, China.
Xiufu ZhangDepartment of Radiology, Chongqing University Jiangjin Hospital, Chongqing, China.
Jun ZhouDepartment of Radiology, Chongqing University Jiangjin Hospital, Chongqing, China.
Hongying LiuDepartment of Oncology, Chongqing University Jiangjin Hospital, Chongqing, China.
Chunrong WuDepartment of Oncology, Chongqing University Jiangjin Hospital, Chongqing, China.
Ruipeng LiangDepartment of Radiology, Chongqing University Jiangjin Hospital, Chongqing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To investigate blood-brain barrier (BBB) permeability abnormalities in cerebral white matter regions of non-brain metastatic lung cancer (LC) patients and their association with histopathological subtypes. Methods: 221 subjects (74 Healthy Controls [HC], 78 LC, 69 LC with Brain Metastasis [LCBM]) were enrolled. LC was subdivided into Adenocarcinoma (ADC), Squamous Cell Carcinoma (SCC), Small Cell Lung Cancer (SCLC). Dynamic Contrast-Enhanced MRI (DCE-MRI) assessed K Results: LC group had K Conclusion: LC impairs BBB integrity via paraneoplastic effects, with subtype heterogeneity: ADC (high perfusion/leakage) involves global white matter; SCLC (prominent interstitial disruption) affects mainly deep regions. Findings aid LC brain metastasis risk stratification and neuroprotective strategies.

Indexed as

blood-brain barrierbrain metastaticcerebral white matterDCE-MRIlung cancer

Identifiers

PMID41809831
PMCPMC12968021

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