ArticleFrontiers in oncology2026
Factors associated with clinical outcomes of breast cancer based on glucose metabolic activity of subcutaneous adipose tissue.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Obesity increases the risk of breast cancer, with dysfunctional metabolic activity in subcutaneous adipose tissue (SAT) implicated as a key underlying mechanism. This study sought to explore the correlation between SAT metabolic activity and clinical prognosis among patients with breast cancer. Methods: Body composition parameters at the level of the third lumbar vertebra and clinicopathological data from 74 patients with breast cancer were collected. Two Cox models were established using the least absolute shrinkage and selection operator (LASSO) for variable selection. The two models were compared using the time-dependent area under the receiver operating characteristic curve (AUC) and the net reclassification index (NRI). Furthermore, the confounding effects on the association among the mean standard uptake value of subcutaneous adipose tissue (SUVmean_SAT), American Joint Committee on Cancer (AJCC) stage, and progression status in patients with breast cancer were assessed. Results: Twenty-five out of 74 patients experienced recurrence during a median follow-up of 18 months. AJCC stage ( Conclusions: A comprehensive assessment incorporating both SUVmean_SAT and AJCC stage may enhance understanding of the impact of adiposity on breast cancer prognosis.
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