ArticleTranslational andrology and urology2026
USP10 regulates HIF2α stability by deubiquitinating HIF2α regardless of
Article in Translational andrology and urology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Hypoxia inducible factor 2α (HIF2α) is a major oncogenic driver in clear cell renal cell carcinoma (ccRCC). HIF2α is upregulated by von Hippel-Lindau ( Methods: We selected three ccRCC cell lines with distinct Results: In our study, the PR-619 inhibitor caused a decrease in the HIF2α protein level in 786-O, OS-RC-2, and SW839 cells, and MG132 treatment increased HIF2α protein expression after PR-619 treatment. Furthermore, the MS, Co-IP and Western blotting results revealed that ubiquitin-specific peptidase 10 (USP10) is a DUB that binds to HIF2α and that depletion of USP10 leads to HIF2α downregulation through promotion of HIF2α ubiquitination. We also confirmed that USP10 expression was upregulated in kidney cancer and had a positive correlation with HIF2α expression in RCC patient samples. Conclusions: Our results suggest that USP10 promotes HIF2α stability.
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