Evidence map›Paper›PMID 41809774›Full record

ArticleJournal of pregnancy2026

The Effect of Hepatitis B Infection on Levels of Fibrinogen, Protein C, and Protein S in Pregnant Women.

Abiba Alhassan Khalifah, Stephen Twumasi, Allwell Adofo Ayirebi, Wina Ivy Ofori Boadu, Francis Agyei Amponsah, Joseph Frimpong, David Amoah Afrifah, Ernest Appiagyei, Albert Ntim Boadu, Daniel Nii Martey Antonio and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pregnancy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Abiba Alhassan KhalifahDepartment of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana, knust.edu.gh.ORCID 0009-0006-2846-4140
Stephen TwumasiDepartment of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana, knust.edu.gh.ORCID 0009-0002-8199-5806
Allwell Adofo AyirebiDepartment of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana, knust.edu.gh.ORCID 0009-0005-0805-9829
Wina Ivy Ofori BoaduDepartment of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana, knust.edu.gh.ORCID 0000-0002-2660-1707
Francis Agyei AmponsahDepartment of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana, knust.edu.gh.ORCID 0000-0002-6604-1281
Joseph FrimpongDepartment of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana, knust.edu.gh.ORCID 0000-0002-9128-7208
David Amoah AfrifahDepartment of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana, knust.edu.gh.
Ernest AppiagyeiDepartment of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana, knust.edu.gh.
Albert Ntim BoaduDepartment of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana, knust.edu.gh.
Daniel Nii Martey AntonioKumasi South Hospital, Kumasi, Ghana.ORCID 0000-0002-8953-5700
Enoch Odame AntoDepartment of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana, knust.edu.gh.ORCID 0000-0001-9023-6612

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Viral hepatitis has been associated with profound alterations in the coagulation system as well as liver biomarkers. Meanwhile, during pregnancy, the coagulation system also undergoes significant changes with an increase in the majority of the clotting factors and a decrease in natural anticoagulants. This study is aimed at evaluating the coagulation profile and liver biomarkers among hepatitis B-infected pregnant women in a Ghanaian population. Methods: This case-control study was conducted at Afrancho Polyclinic in the Ashanti Region, Ghana from January 2022 to July 2023. This study recruited 90 hepatitis B pregnant women as cases and 90 hepatitis B-negative pregnant women as controls. A structured questionnaire was used to obtain sociodemographic, obstetric, and clinical data from each participant. Results: Levels of albumin, fibrinogen (4.09 [3.57-5.94] vs. 6.89 [5.43-9.08], Conclusion: Pregnant women with hepatitis B infection present with significant changes in their coagulation parameters, natural anticoagulants, and liver biomarkers. Furthermore, fibrinogen, protein C, and aPTT showed accurate diagnostic potential in detecting chronic viral hepatitis B infection and may be valuable surrogate indicators for managing chronic hepatitis-related complications.

Indexed as

FibrinogenHepatitis BPregnancy Complications, InfectiousProtein CProtein SAdultBiomarkersCase-Control StudiesFemaleGhanaHumansPregnancyYoung AdultBiomarkersFibrinogenProtein CProtein SalbuminaPTTbilirubinfibrinogenhepatitis Bliver enzymespregnancyprotein Cprotein SPT

Identifiers

PMID41809774
PMCPMC12968073

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.