ArticleJournal of inflammation research2026
Association of Blood Eosinophil Counts with Expiratory Airflow Limitation: A Multi-Ethnicity Observational Study.
Article in Journal of inflammation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
12 authors.
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Abstract
Purpose: While elevated blood eosinophil counts (BECs) are established biomarkers in asthma and chronic obstructive pulmonary disease, their impact on lung function in general populations remains less defined. This multi-ethnicity study examined BEC-lung function associations across diverse populations and employed Mendelian randomization (MR) to explore causal mechanisms. Patients and methods: Integrated cross-sectional analyses involved three cohorts: Hongtong (n=13,868), NHANES (n=11,833), UK Biobank (UKB; n=428,610). Longitudinal assessment used UKB data (n=38,532). Multivariable regression assessed BEC associations with FEV Results: BECs consistently showed inverse associations with FEV Conclusion: BECs show a significant and independent association with lung function impairment at the population level. MR analyses provide supportive evidence for a potential causal role, identifying distinct patterns of airway obstruction in Asian populations versus broader lung function deficits in Europeans. Variations by sex, ancestry, age, and smoking underscore demographic considerations in eosinophil-related respiratory health. These findings suggest the potential utility of monitoring BECs in asymptomatic individuals and warrant further investigation into personalized prevention strategies.
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