Evidence map›Paper›PMID 41809722›Full record

ArticleClinical kidney journal2026

Intra-individual fluctuations in alkaline phosphatase predict mortality and CKD progression: insights from a large CKD cohort.

Yaerim Kim, Ping-Hsun Wu, Soie Kwon, Seung Hyun Han, Jeonghwan Lee, Ming-Yen Lin, Yi-Wen Chiu, Nak-Hoon Son, Jin Hyuk Paek, Dong Ki Kim and 4 more

Abstract read
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In one paragraph

Article in Clinical kidney journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yaerim KimDepartment of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea.ORCID https://orcid.org/0000-0003-1596-1528
Ping-Hsun WuDivision of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Soie KwonDepartment of Internal Medicine, Chung-Ang University Hospital, Seoul, Korea.
Seung Hyun HanDepartment of Internal Medicine, Seoul National University Hospital, Seoul, Korea.ORCID https://orcid.org/0000-0001-5132-5452
Jeonghwan LeeDepartment of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea.
Ming-Yen LinDivision of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.ORCID https://orcid.org/0000-0002-8194-4833
Yi-Wen ChiuDivision of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.ORCID https://orcid.org/0000-0001-6840-5440
Nak-Hoon SonDepartment of Statistics, Keimyung University, Daegu, Korea.
Jin Hyuk PaekDepartment of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea.
Dong Ki KimDepartment of Internal Medicine, Seoul National University Hospital, Seoul, Korea.
Seungyeup HanDepartment of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea.
Chun Soo LimDepartment of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea.
Shang-Jyh HwangDivision of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.ORCID https://orcid.org/0000-0002-9404-3305
Jung Pyo LeeDepartment of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea.ORCID https://orcid.org/0000-0002-4714-1260

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Elevated alkaline phosphatase (ALP) levels are associated with mortality. However, the significance of ALP variability, particularly in chronic kidney disease (CKD), has not been well explored. This study examined the associations of baseline ALP and its variability with all-cause mortality and end-stage kidney disease (ESKD) in patients with CKD. Methods: This retrospective cohort study analyzed data from tertiary hospitals in Taiwan and Korea (2001-2021). Adults with CKD, defined by at least two estimated glomerular filtration rate (eGFR) values <60 ml/min/1.73 m Results: In the baseline ALP cohort ( Conclusion: Given the significant impact of ALP levels and their variability on mortality and kidney disease progression, targeted monitoring and stabilization of ALP over time may help improve long-term outcomes in patients with CKD.

Indexed as

alkaline phosphatasechronic kidney diseasemortalityvariability

Identifiers

PMID41809722
PMCPMC12968615

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.