ArticleInternational journal of women's health2026
Live Births Following IVF-FET in Two Adult Sisters with Nonclassic P450 Oxidoreductase Deficiency: A Case Report Identifying a Novel POR Variant.
Article in International journal of women's health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Cytochrome P450 oxidoreductase deficiency (PORD) is an exceptionally rare form of congenital adrenal hyperplasia (CAH) characterized by impaired activity of multiple microsomal cytochrome P450 enzymes. In adult women, PORD frequently presents with nonspecific reproductive manifestations such as menstrual irregularities, infertility, and ovarian cysts, often mimicking polycystic ovary syndrome (PCOS) or premature ovarian insufficiency (POI). To date, successful pregnancies in affected women remain extremely rare. Case Presentation: We describe two biological sisters with compound heterozygous Conclusion: These cases represent the first report of two siblings with nonclassic PORD achieving live births through IVF-FET. Moreover, we identified a previously unreported
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