Evidence map›Paper›PMID 41809563›Full record

ArticleHuman mutation2026

Oncological Genetic Counseling in Hereditary Breast and Ovarian Cancers and Lynch Syndrome High-Risk Subjects: Evaluation of Efficacy and Outcomes Using the Genomics Outcome Scale.

Elena Maccaroni, Rebecca Chiariotti, Riccardo Giampieri, Francesca Bianchi, Cristiana Brugiati, Laura Belvederesi, Elisa Ambrosini, Natalia Chiodi, Emma Nicol Serritelli, Francesca Morgese and 14 more

Abstract read
In one paragraph

Article in Human mutation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Elena MaccaroniDepartment of Oncology, Azienda Ospedaliero Universitaria delle Marche, Ancona, Italy.ORCID https://orcid.org/0000-0003-3212-4246
Rebecca ChiariottiDepartment of Oncology, Università Politecnica delle Marche, Ancona, Italy, univpm.it.
Riccardo GiampieriDepartment of Oncology, Università Politecnica delle Marche, Azienda Ospedaliero Universitaria delle Marche, Ancona, Italy, univpm.it.
Francesca BianchiDepartment of Oncology, Università Politecnica delle Marche, Azienda Ospedaliero Universitaria delle Marche, Ancona, Italy, univpm.it.
Cristiana BrugiatiDepartment of Oncology, Università Politecnica delle Marche, Ancona, Italy, univpm.it.
Laura BelvederesiDepartment of Oncology, Università Politecnica delle Marche, Ancona, Italy, univpm.it.
Elisa AmbrosiniDepartment of Oncology, Università Politecnica delle Marche, Ancona, Italy, univpm.it.
Natalia ChiodiDepartment of Oncology, Università Politecnica delle Marche, Ancona, Italy, univpm.it.
Emma Nicol SerritelliDepartment of Oncology, Università Politecnica delle Marche, Ancona, Italy, univpm.it.
Francesca MorgeseDepartment of Oncology, Azienda Ospedaliero Universitaria delle Marche, Ancona, Italy.
Veronica AgostinelliDepartment of Oncology, Azienda Ospedaliero Universitaria delle Marche, Ancona, Italy.
Giulia MentrastiDepartment of Oncology, Azienda Ospedaliero Universitaria delle Marche, Ancona, Italy.
Cecilia CopparoniDepartment of Oncology, Università Politecnica delle Marche, Ancona, Italy, univpm.it.
Alice MagnariniDepartment of Oncology, Università Politecnica delle Marche, Ancona, Italy, univpm.it.
Chiara De FilippisDepartment of Oncology, Università Politecnica delle Marche, Ancona, Italy, univpm.it.
Elena BurattiniDepartment of Oncology, Università Politecnica delle Marche, Ancona, Italy, univpm.it.
Raffaella BracciMedical Oncology Unit, AST1, Pesaro, Italy.
Rita ChiariMedical Oncology Unit, AST1, Pesaro, Italy.
Michela Del PreteMedical Oncology Unit, Ospedale A. Murri, Fermo, Italy.
Renato BisonniMedical Oncology Unit, Ospedale A. Murri, Fermo, Italy.
Luca FaloppiMedical Oncology Unit, Ospedali Santa Maria Della Pietà e Bartolomeo Eustachio-AST di Macerata, Camerino, San Severino Marche, Italy.
Nicola BattelliMedical Oncology Unit, Macerata Hospital, Macerata, Italy.
Rosa Rita SilvaMedical Oncology Unit, AST2, Fabriano, Italy.
Rossana BerardiDepartment of Oncology, Università Politecnica delle Marche, Azienda Ospedaliero Universitaria delle Marche, Ancona, Italy, univpm.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Validated tools assessing oncological genetic counseling (OGC) quality are lacking. Methods: We assessed OCG effectiveness using italian-translated version of the Genomics Outcome Scale (GOS) questionnaire. Clinical variables were collected and their association with different answers was assessed by Fisher's exact test or Chi-square test for either dichotomous or other categorical variables, respectively, with level of statistical significance Results: Between November 2024 and February 2025, 209 subjects who received the complete OGC program at Our Center responded to the questionnaire; median age was 56 years (25-81). Most (76%) had breast cancer, 72% received a negative test, 15% positive test, and 13% noninformative test with variant of unknown significance (VUS). Most patients answered affirmatively to Question 1, focused on OGC understanding: age ( Conclusions: GOS questionnaire confirms that OGC is useful and effective to inform patients about their condition, surveillance, and prevention. Higher levels of empowerment were seen in younger patients and those with higher education.

Indexed as

Breast NeoplasmsColorectal Neoplasms, Hereditary NonpolyposisGenetic CounselingHereditary Breast and Ovarian Cancer SyndromeOvarian NeoplasmsAdultAgedAged, 80 and overFemaleGenetic Predisposition to DiseaseGenetic TestingGenomicsHumansMiddle AgedSurveys and Questionnairesgenetic testGenomics Outcome scalehereditary breast and ovarian cancershereditary cancersLynch syndromeoncological genetic counseling

Identifiers

PMID41809563
PMCPMC12968728

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.