Evidence map›Paper›PMID 41809523›Full record

ReviewFrontiers in pediatrics2026

Ralstonia pickettii as an emerging pediatric pathogen: a mini-review of current evidence.

Christian Alberto Rodriguez-Saldaña, Mirtha Chiroque-Zavala, Milagros Quindes-Jaimes, Gianella María Muñoz-Vílchez, Karla Inés Alcántara-Sánchez, Adriana Montoya-Reátegui, Anabella Quiroga-Taboada, Luis Gabriel Farfán-Chávez, Daniel Reyes-Chávez, Juan José Flores-Rodriguez

Abstract readReview
In one paragraph

Review in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Christian Alberto Rodriguez-SaldañaDepartment of Pediatrics, Peru-Korea Friendship Santa Rosa II-2 Hospital, Piura, Peru.
Mirtha Chiroque-ZavalaDepartment of Pediatrics, Peru-Korea Friendship Santa Rosa II-2 Hospital, Piura, Peru.
Milagros Quindes-JaimesDepartment of Pediatrics, Peru-Korea Friendship Santa Rosa II-2 Hospital, Piura, Peru.
Gianella María Muñoz-VílchezDepartment of Pediatrics, Peru-Korea Friendship Santa Rosa II-2 Hospital, Piura, Peru.
Karla Inés Alcántara-SánchezDepartment of Pediatrics, Peru-Korea Friendship Santa Rosa II-2 Hospital, Piura, Peru.
Adriana Montoya-ReáteguiDepartment of Infectious Diseases, Peru-Korea Friendship Santa Rosa II-2 Hospital, Piura, Peru.
Anabella Quiroga-TaboadaDepartment of Pediatrics, Hospital II Talara, Piura, Peru.
Luis Gabriel Farfán-ChávezDepartment of Infectious Diseases, José Cayetano Heredia III-1 Hospital, EsSalud, Piura, Peru.
Daniel Reyes-ChávezDepartment of Infectious Diseases, José Cayetano Heredia III-1 Hospital, EsSalud, Piura, Peru.
Juan José Flores-RodriguezDepartment of Internal Medicine, José Cayetano Heredia III-1 Hospital, EsSalud, Piura, Peru.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Ralstonia pickettii has gained relevance in pediatric healthcare due to its persistence in water systems, biofilm formation and contamination of medical solutions. This review summarizes current evidence on its epidemiology, environ-mental reservoirs, clinical features, diagnostic limitations and therapeutic considera-tions in children. Methods: A narrative search was conducted in PubMed, Scopus, Web of Science and Embase for studies published from January 1990 to 30 November 2025. Pediatric cases, outbreak reports, environmental studies with clinical relevance and microbiological reviews were included. Heterogeneity in design and reporting justified a narrative synthesis. Results: R. pickettii is the predominant Ralstonia species in pedi-atric infections and is closely linked to contaminated aqueous products and respiratory equipment. Neonates and immunocompromised children are most affected, with man-ifestations ranging from colonization to severe sepsis. Diagnostic systems frequently misidentify the organism, and molecular tools improve accuracy when combined with clinical assessment. Susceptibility patterns are variable and influenced by intrinsic re-sistance mechanisms and biofilm. Effective treatment often requires targeted therapy and device removal. Outbreak investigations consistently identify contaminated solu-tions and water systems as primary sources. Conclusions: R. pickettii is an emerging pathogen in pediatric care. Improving diagnostic accuracy, strengthening environ-mental control and ensuring safe handling of water-based solutions and medical devices are essential to reduce its clinical impact.

Indexed as

bacteremiabio-filmcontaminated solutionshealthcare-associated infectionneonatal intensive careoutbreak investigationpediatric infectionsRalstonia pickettii

Identifiers

PMID41809523
PMCPMC12968233

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.