Evidence map›Paper›PMID 41809488›Full record

ArticleFrontiers in aging neuroscience2026

A transcriptomic resource for glial GABA-associated ASH neuronal aging and candidate pathways.

Umar Al-Sheikh, Hankui Cheng, Ahmed Abdulsalam Ali Bakrbaldawi, Longyuan He, Du Chen, Renya Zhan, Lijun Kang, Yongming Zhang

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Article in Frontiers in aging neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Umar Al-SheikhDepartment of Ophthalmology of the Fourth Affiliated Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Yiwu, China.
Hankui ChengDepartment of Ophthalmology of the Fourth Affiliated Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Yiwu, China.
Ahmed Abdulsalam Ali BakrbaldawiLiangzhu Laboratory, MOE Frontier Science Center for Brain Science and Brain-Machine Integration, Zhejiang University, Hangzhou, China.
Longyuan HeDepartment of Neurosurgery of the First Affiliated Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Zhejiang, China.
Du ChenDepartment of Ophthalmology of the Fourth Affiliated Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Yiwu, China.
Renya ZhanDepartment of Neurosurgery of the First Affiliated Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Zhejiang, China.
Lijun KangDepartment of Ophthalmology of the Fourth Affiliated Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Yiwu, China.
Yongming ZhangDepartment of Ophthalmology of the Fourth Affiliated Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Yiwu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Neuronal aging is tightly linked to neurodegeneration with dysregulation of GABA (gamma-aminobutyric acid), the primary inhibitory neurotransmitter, contributing to age-associated neuronal impairment. Our prior work demonstrated that restoring the key GABA-synthesizing enzyme UNC-25 (glutamic acid decarboxylase, GAD) in Methods: ASH neurons from day 1 and day 7 nematodes were isolated and FACS-purified (Psra-6::RFP+/Pgpa-4::GFP-) from three distinct groups: Wild-type, Results: Here, we present transcriptomic data of glutamatergic ASH sensory neurons (a critical target of aging-related neurodegeneration) from three aging groups: wild-type worms, Conclusions: This work establishes a valuable transcriptomic resource for glial GABA-associated ASH neuronal aging and identifies candidate pathways, offering critical molecular insights to dissect age-related neurodegeneration mechanisms and inform potential therapeutic targets.

Indexed as

C. elegansGABAglia-neuronal interactionneuronal agingtranscriptomic analyses

Identifiers

PMID41809488
PMCPMC12968253

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.