Evidence map›Paper›PMID 41809483›Full record

ArticleWorld journal of hepatology2026

Fatigue and circadian rhythm in non-cirrhotic primary biliary cholangitis: An exploratory comparison with primary sclerosing cholangitis and healthy controls.

Armando Curto, Michele Tanturli, Rocco Gabriele Iamello, Pietro Rossi, Giulia Mengozzi, Leonardo Dei, Tommaso Mello, Tommaso Innocenti, Gabriele Dragoni, Andrea Galli and 1 more

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In one paragraph

Article in World journal of hepatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Armando CurtoDepartment of Experimental and Clinical Biomedical Sciences "Mario Serio", Gastroenterology Research Unit, University of Florence, Florence 50134, Tuscany, Italy.
Michele TanturliDepartment of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Florence 50134, Tuscany, Italy.
Rocco Gabriele IamelloDepartment of Experimental and Clinical Biomedical Sciences "Mario Serio", Gastroenterology Research Unit, University of Florence, Florence 50134, Tuscany, Italy.
Pietro RossiDepartment of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Florence 50134, Tuscany, Italy.
Giulia MengozziDepartment of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Florence 50134, Tuscany, Italy.
Leonardo DeiDepartment of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Florence 50134, Tuscany, Italy.
Tommaso MelloDepartment of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Florence 50134, Tuscany, Italy.
Tommaso InnocentiDepartment of Experimental and Clinical Biomedical Sciences "Mario Serio", Gastroenterology Research Unit, University of Florence, Florence 50134, Tuscany, Italy.
Gabriele DragoniDepartment of Experimental and Clinical Biomedical Sciences "Mario Serio", Gastroenterology Research Unit, University of Florence, Florence 50134, Tuscany, Italy.
Andrea GalliDepartment of Experimental and Clinical Biomedical Sciences "Mario Serio", Gastroenterology Research Unit, University of Florence, Florence 50134, Tuscany, Italy.
Erica Nicola LynchDepartment of Experimental and Clinical Biomedical Sciences "Mario Serio", Gastroenterology Research Unit, University of Florence, Florence 50134, Tuscany, Italy. ericanicola.lynch@unifi.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFatigue is common and debilitating in primary biliary cholangitis (PBC) without clear relation to disease stage; mechanisms remain unclear. Circadian disruption is reported in end-stage liver disease, but evidence in non-cirrhotic PBC, and links to fatigue, is scarce.

aimTo investigate the severity and phenotype of fatigue, daytime sleepiness, and chronotype in non-cirrhotic PBC, and compare findings with matched healthy controls (HC) and non-cirrhotic primary sclerosing cholangitis (PSC).

methodsParticipants completed the Fatigue Impact Scale, Epworth Sleepiness Scale, and Morningness-Eveningness Questionnaire Self-Assessment. Demographics, sleep habits, employment, and fatigue subtype (mental

resultsWe enrolled 152 individuals: 61 PBC, 30 PSC, and 61 HC. Global fatigue scores did not differ across groups. Muscular fatigue predominated in PBC/PSC, whereas HC more often reported mental fatigue; this pattern persisted after stratifying by employment and sex. In adjusted analyses, HC had lower odds of muscular fatigue than PBC [odd ratio (OR) = 0.30, 95% confidence interval (CI): 0.14-0.63;

conclusionIn non-cirrhotic PBC, fatigue shows a predominantly muscular phenotype independent of demographics/occupation and decoupled from conventional disease metrics. Chronotype and daytime alertness appear largely preserved, with age driving modest morningness. Findings support integrating fatigue phenotyping into assessment, prioritizing muscle-targeted interventions, and using carefully selected controls and objective endpoints in future studies.

Indexed as

Cholestatic disordersChronotypeDaytime sleepinessMentalMuscularPrimary biliary cholangitisPrimary sclerosing cholangitis

Identifiers

PMID41809483
PMCPMC12968687

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.