Evidence map›Paper›PMID 41809436›Full record

ArticleBrain communications2026

Tau biomarkers in Special Operations Forces with repeated blast exposure: a cross-sectional study.

Chieh-En Jane Tseng, Jennifer Guo, Natalie Gilmore, Douglas N Greve, Isabella R McKinney, Brian C Healy, Samantha L Tromly, Kristen Dams-O'Connor, Christine L Mac Donald, Daniel P Perl and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Chieh-En Jane TsengAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.ORCID https://orcid.org/0000-0003-0592-335X
Jennifer GuoDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Natalie GilmoreDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Douglas N GreveAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.
Isabella R McKinneyDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Brian C HealyBiostatistics Center, Massachusetts General Hospital, Boston, MA 02114, USA.
Samantha L TromlyInstitute of Applied Engineering, University of South Florida, Tampa, FL 33612, USA.
Kristen Dams-O'ConnorDepartment of Rehabilitation and Human Performance, Icahn School of Medicine, NewYork, NY 10029, USA.
Christine L Mac DonaldDepartment of Neurological Surgery, University of Washington, Seattle, WA 98195, USA.
Daniel P PerlDepartment of Pathology, F. Edward Hébert School of Medicine, Uniformed Services University, Bethesda, MD 20814, USA.
Jacob M HookerAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.
Yelena G BodienDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Brian L EdlowAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.ORCID https://orcid.org/0000-0001-7235-8456
William T KimberlyDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Nicole R ZürcherAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

US Special Operations Forces (SOF) personnel endure repeated blasts throughout training and combat. Recent human postmortem, neuroimaging and blood proteomic work suggest that tau pathology is present following repeated blast exposure. This study aimed to determine whether blood tau markers are associated with brain tau paired helical filaments (PHFs) in SOF personnel. Twenty-eight active-duty SOF completed a positron emission tomography-magnetic resonance imaging scan with the PHF-specific radiotracer fluorine-18 MK6240 ([

Indexed as

blood biomarkerneuroimagingtau

Identifiers

PMID41809436
PMCPMC12967882

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.