Evidence map›Paper›PMID 41809389›Full record

ReviewLancet regional health. Americas2026

Yellow fever in Latin America and the escalating risks in a changing eco-epidemiological landscape: a review.

Esteban Ortiz-Prado, Jose G Prieto-Marin, Juan S Izquierdo-Condoy, Jorge Vasconez-Gonzalez, Wilder Andrés Villamil-Parra, Ginés Viscor, Óscar A Niño-Méndez, Jorge Enrique Correa-Bautista, Marta Rusiñol, Doménica Cevallos-Robalino and 2 more

Abstract readReview
In one paragraph

Review in Lancet regional health. Americas, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Esteban Ortiz-PradoOne Health Research Group, Universidad de Las Américas (UDLA), Quito, Ecuador.
Jose G Prieto-MarinOne Health Research Group, Universidad de Las Américas (UDLA), Quito, Ecuador.
Juan S Izquierdo-CondoyOne Health Research Group, Universidad de Las Américas (UDLA), Quito, Ecuador.
Jorge Vasconez-GonzalezOne Health Research Group, Universidad de Las Américas (UDLA), Quito, Ecuador.
Wilder Andrés Villamil-ParraDepartamento de Movimiento Corporal Humano, Facultad de Enfermería y Rehabilitación, Universidad de La Sabana, Chía, Colombia.
Ginés ViscorSecció de Fisiologia, Departament de Biologia Cel·lular, Fisiologia i Immunologia, Facultat de Biologia Universitat de Barcelona, Barcelona, Spain.
Óscar A Niño-MéndezFacultad de Ciencias del Deporte y la Educación Física, Universidad de Cundinamarca, Colombia.
Jorge Enrique Correa-BautistaFacultad de Ciencias del Deporte y la Educación Física, Universidad de Cundinamarca, Colombia.
Marta RusiñolDepartament de Genètica, Microbiologia i Estadística, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain.
Doménica Cevallos-RobalinoSecretaría de Salud, Distrito Metropolitano de Quito, Quito, Ecuador.
Juan-Carlos NavarroEmerging and Neglected Diseases Group, Universidad Internacional SEK (UISEK), Quito, Ecuador.
Jorge A Villalobos-MadrizEscuela de Farmacia, Universidad Latina, San Jose, Costa Rica.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Yellow fever (YF) remains a major public health concern in Latin America. We characterise the early-2025 outbreak, compare it with prior waves-especially Southeast Brazil (2016-2018)-and examine environmental, structural, and policy-related drivers. We reviewed regional surveillance data and mortality records from January to April 2025, comparing them to historical outbreak data. Case fatality rate (CFR), geographic spread, and population vulnerability patterns were analyzed. We also reviewed published literature and health alerts to contextualize contributing factors. In 2025, 301 confirmed cases and 124 deaths were reported (CFR 41.1%), mostly in Bolivia, Brazil, Colombia, and Peru, concentrated among unvaccinated populations at the forest-urban interface. Transmission remains sylvatic, but peri-urban spillover risk is rising. Deforestation, climate variability, cross-border migration, and political instability heighten vulnerability; surveillance is fragmented and vaccine uptake insufficient in high-risk groups. YF is re-emerging through intertwined biological, ecological, and socio-political forces. Preventing another large-scale epidemic requires strengthened, integrated surveillance, including Non-Human Primates (NHP) epizootics, equity-centred immunisation in remote areas, and coordinated regional action focused on prevention, early detection, and health-system resilience.

Indexed as

Latin AmericaOutbreakSurveillanceVaccinationYellow fever

Identifiers

PMID41809389
PMCPMC12969618

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.