ArticleMaterials today. Bio2026
Dextran-based microneedle patch Co-delivering safflower polysaccharide and ROS-responsive tetramethylpyrazine micelles for diabetic wound repair.
Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Biomedical Hydrogels Based on Natural Polysaccharides: Structural Design.Gels (Basel, Switzerland) · 2026Review
- Innovative microneedle-integrated hydrogels: a promising strategy for diabetic foot ulcer management.Frontiers in bioengineering and biotechnology · 2026Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetic wounds remain a major health concern due to impaired healing from persistent inflammation, oxidative stress, and compromised neurovascular regeneration. Conventional therapies are often insufficient to modulate the multifaceted pathological microenvironment of diabetic wound, underscoring the urgent need for multifunctional therapeutic strategies. In this study, we developed a polysaccharide-based hydrogel microneedle (MN) system, co-delivering tetramethylpyrazine (TMP) and safflower polysaccharide (SPS) to promote diabetic wound healing through reactive oxygen species (ROS)-responsive release and neurovascular regeneration. SPS was incorporated into a methacrylated dextran (DexMA)-based hydrogel matrix. Meanwhile, the hydrophobic TMP was encapsulated into ROS-responsive micelles formed by amphiphilic poly(propylene sulfide)-hyaluronic acid (PPS-HA), which served as both a redox-sensitive carrier and a hydrophilic polysaccharide component. The resulting D/SPS/T@P-H MN patch demonstrated strong mechanical integrity, dermal penetration capability, and sustained release behavior.
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