Evidence map›Paper›PMID 41809374›Full record

ArticleMaterials today. Bio2026

Functional restoration of uterine architecture and fertility via a 3D-printed biomimetic scaffold: The role of macrophage-driven immunomodulation.

Qianqian Wei, Jing Zhang, Jiahao Weng, Jiawen Lan, Jing He, Yuewei Chen, Zhongfei Zou, Yong He, Yanpeng Wang, Jing Shu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Qianqian WeiCenter for Reproductive Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Jing ZhangCenter for Reproductive Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Jiahao WengState Key Laboratory of Fluid Power and Mechatronic Systems & Liangzhu Laboratory, School of Mechanical Engineering, Zhejiang University, Hangzhou, 310027, China.
Jiawen LanCenter for Reproductive Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Jing HeCenter for Reproductive Medicine, Department of Gynecology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Yuewei ChenSchool of Mechanical Engineering, Guizhou University, Guiyang, 550025, China.
Zhongfei ZouSchool of Mechanical Engineering, Guizhou Institute of Technology, Guiyang, 550003, China.
Yong HeState Key Laboratory of Fluid Power and Mechatronic Systems & Liangzhu Laboratory, School of Mechanical Engineering, Zhejiang University, Hangzhou, 310027, China.
Yanpeng WangCenter for Reproductive Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Jing ShuCenter for Reproductive Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The structural complexity of the uterus makes identifying biomaterials and scaffold designs for supporting functional tissue regeneration challenging. Poly(L-lactide-co-caprolactone) (PLCL) has gained attention due to its biocompatibility and tunable degradation profile. In this study, a three-layered PLCL scaffold was fabricated via melt electrowriting (MEW) 3D printing to mimic the mechanical properties of the native uterine matrix. Using a mouse model of severe uterine injury, we demonstrated that the PLCL scaffold markedly promoted structural repair and functional recovery, as evidenced by improved pregnancy outcomes. Mechanistically, the scaffold enhanced macrophage recruitment and skewed their polarization toward an M2 phenotype, accompanied by upregulation of the hallmark genes

Indexed as

Macrophage polarizationPLCLRegenerative medicineTissue engineeringUterine defect

Identifiers

PMID41809374
PMCPMC12969655

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.