Evidence map›Paper›PMID 41809369›Full record

ArticleMolecular therapy. Oncology2026

Outcomes of point-of-care manufactured CAR T cell therapy for B cell acute lymphoblastic leukemia and non-Hodgkin lymphoma in Vietnam.

Liem Thanh Nguyen, Duy D Nguyen, Quoc Khanh Bach, Lan T M Dao, Trang Thi Kieu Phan, Hoang-Phuong Nguyen, Hong-Nhung Dao, Trang H Pham, Phuong T Pham, Hien T Mai and 11 more

Abstract read
In one paragraph

Article in Molecular therapy. Oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Liem Thanh NguyenVinmec Research Institute of Stem Cell and Gene Technology, VinUniversity, Hanoi, Vietnam.
Duy D NguyenVinmec Smart City International Hospital, Vinmec Health Care System, 2A Tay Mo Street, Hanoi 12009, Vietnam.
Quoc Khanh BachNational Institute of Hematology and Blood Transfusion (NIHBT), 5 Pham Van Bach, Cau Giay District, Hanoi, Vietnam.
Lan T M DaoVinmec Research Institute of Stem Cell and Gene Technology, VinUniversity, Hanoi, Vietnam.
Trang Thi Kieu PhanVinmec Research Institute of Stem Cell and Gene Technology, VinUniversity, Hanoi, Vietnam.
Hoang-Phuong NguyenVinmec Research Institute of Stem Cell and Gene Technology, VinUniversity, Hanoi, Vietnam.
Hong-Nhung DaoVinmec Research Institute of Stem Cell and Gene Technology, VinUniversity, Hanoi, Vietnam.
Trang H PhamVinmec Research Institute of Stem Cell and Gene Technology, VinUniversity, Hanoi, Vietnam.
Phuong T PhamDepartment of Regenerative Medicine and Cell Therapy, Vinmec Healthcare System, Hanoi, Vietnam.
Hien T MaiDepartment of Regenerative Medicine and Cell Therapy, Vinmec Healthcare System, Hanoi, Vietnam.
Viet Huong T PhamVinmec Smart City International Hospital, Vinmec Health Care System, 2A Tay Mo Street, Hanoi 12009, Vietnam.
Thanh Mai T NguyenDepartment of Regenerative Medicine and Cell Therapy, Vinmec Healthcare System, Hanoi, Vietnam.
Van Binh LeVinmec Times City International Hospital, Vinmec Health Care System, 458 Minh Khai, Hanoi 11622, Vietnam.
Nam Lam PhungVinmec Times City International Hospital, Vinmec Health Care System, 458 Minh Khai, Hanoi 11622, Vietnam.
Ngoc Quang NguyenVinmec Times City International Hospital, Vinmec Health Care System, 458 Minh Khai, Hanoi 11622, Vietnam.
Michelle L HermistonCollege of Health Sciences, VinUniversity, Vinhomes Ocean Park, Gia Lam District, Hanoi 1310, Vietnam.
Quynh Lan PhanVinmec Times City International Hospital, Vinmec Health Care System, 458 Minh Khai, Hanoi 11622, Vietnam.
Do Quang Trung NguyenVinmec Times City International Hospital, Vinmec Health Care System, 458 Minh Khai, Hanoi 11622, Vietnam.
Lan MaiNational Institute of Hematology and Blood Transfusion (NIHBT), 5 Pham Van Bach, Cau Giay District, Hanoi, Vietnam.
Quoc Nhat NguyenNational Institute of Hematology and Blood Transfusion (NIHBT), 5 Pham Van Bach, Cau Giay District, Hanoi, Vietnam.
Van T HoangVinmec Research Institute of Stem Cell and Gene Technology, VinUniversity, Hanoi, Vietnam.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chimeric antigen receptor (CAR) T cell therapy has transformed the treatment of relapsed/refractory (R/R) B cell acute lymphoblastic leukemia (ALL) and non-Hodgkin lymphoma (NHL), but access remains limited in resource-constrained settings. This phase I study evaluated the safety and feasibility of point-of-care (PoC) manufactured CD19-targeted CAR T cell therapy in Vietnamese patients. Between August 2023 and June 2025, 16 patients, eight with R/R ALL and eight with R/R NHL, were enrolled. All received fresh CAR T cells produced on-site using the CliniMACS Prodigy system, with a median dose of 1.9 × 10

Indexed as

acute lymphoblastic leukemiaCAR T-cell therapycell therapyCRSglobal health oncologyICANSnon-Hodgkin lymphomapoint-of-care manufacturingresource-constrained settings

Identifiers

PMID41809369
PMCPMC12969028

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.