ArticleWorld journal of gastrointestinal surgery2026
Serum inflammatory biomarkers can predict clinical outcomes in patients with sepsis-associated gastrointestinal dysfunction.
Article in World journal of gastrointestinal surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundEffective predictive indicators for clinical outcomes in septic patients with gastrointestinal dysfunction (GID) remain lacking.
aimTo evaluate the relationship between serum inflammatory biomarkers (SIBs) and clinical outcomes in patients with sepsis-induced GID.
methodsA total of 117 sepsis-induced GID patients were selected (January 2021 to January 2025). They were grouped into poor [
resultsThe groups were similar in age, sex, body mass index, comorbidities, and major infection site. The poor prognosis group exhibited elevated APACHE II, SOFA, PCT, CRP, IL-6, IL-10, and TNF-α than the good prognosis cohort. SIBs correlated positively with both APACHE II and SOFA scores. When used to predict outcomes individually, SIBs yielded an area under the curve range of 0.660-0.780 in septic patients with GID, whereas combined biomarker analysis increased the area under the curve to 0.906. APACHE II, SOFA, PCT, CRP, IL-6, and TNF-α acted as independent predictors of prognosis.
conclusionSIBs correlate intimately with clinical outcomes in sepsis-induced GID patients.
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