ArticleWorld journal of gastrointestinal surgery2026
Association between type 2 diabetes mellitus and colorectal adenoma: A retrospective study with insights into Wnt/β-Catenin/TCF7L2 pathway activation.
Article in World journal of gastrointestinal surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPrevious studies have confirmed the association of type 2 diabetes mellitus with the occurrence of colorectal polyps and adenomas. However, the current research results concerning the extent and specific effect of type 2 diabetes mellitus on the occurrence and development of colorectal adenomas remain inconsistent.
aimTo identify and investigate the association between type 2 diabetes mellitus and colorectal adenoma pathogenesis.
methodsThis retrospective case-control study reviewed all colonoscopies and definite pathology diagnoses performed in patients admitted to the Department of Gastroenterology, Nanshan People's Hospital, from January 2015 to December 2017. Colorectal epithelium samples from colorectal adenomas were categorized into two groups: Patients with diabetes mellitus (A + D group;
resultsType 2 diabetes mellitus was significantly associated with colorectal adenomas (odds ratio = 2.263, 95% confidence interval = 1.252-4.09,
conclusionThe results of this small-scale retrospective cohort study indicate a significant association between type 2 diabetes mellitus and colorectal adenomas. The clinical sample experimental evidence in this study indicates that the increased activity and expression of Wnt/β-catenin/TCF7L2 is one of the mechanisms of type 2 diabetes mellitus and colorectal adenomas.
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