Evidence map›Paper›PMID 41809325›Full record

Trial reportWorld journal of gastrointestinal surgery2026

Neurotrophin-3 rs1805149A>G variant in Hirschsprung disease: An investigative study.

Xiao-Gang Xu, Yan-Qing Liu, Meng-Long Lan, Fei Liu, Hui-Min Xia, Ji-Xiao Zeng

Abstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in World journal of gastrointestinal surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiao-Gang XuDepartment of Pediatric Surgery, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, National Children's Medical Center for South Central Region, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou 510623, Guangdong Province, China.
Yan-Qing LiuDepartment of Pediatric Surgery, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, National Children's Medical Center for South Central Region, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou 510623, Guangdong Province, China.
Meng-Long LanDepartment of Pediatric Surgery, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, National Children's Medical Center for South Central Region, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou 510623, Guangdong Province, China.
Fei LiuDepartment of Pediatric Surgery, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, National Children's Medical Center for South Central Region, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou 510623, Guangdong Province, China.
Hui-Min XiaDepartment of Pediatric Surgery, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, National Children's Medical Center for South Central Region, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou 510623, Guangdong Province, China.
Ji-Xiao ZengDepartment of Pediatric Surgery, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, National Children's Medical Center for South Central Region, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou 510623, Guangdong Province, China. zengjixiao@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHirschsprung disease (HSCR) is a congenital disorder of the enteric nervous system (ENS) caused by defective migration of neural crest cells. Genetic factors, including neurotrophic genes such as neurotrophin-3 (

aimTo investigate the association between the

methodsA study was conducted involving 1470 HSCR patients and 1473 healthy controls. Genomic DNA was extracted and genotyping of the

resultsThe distribution of genotypes (AA, AG, GG) and allelic frequencies (A and G) showed no statistically significant differences between HSCR patients and controls. No association was found between the rs1805149 variant and specific clinical subtypes of HSCR.

conclusionThe

Indexed as

Enteric nervous systemGenetic susceptibilityHirschsprung diseaseNeurotrophin-3Single nucleotide polymorphism

Identifiers

PMID41809325
PMCPMC12968700

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.