ArticleWorld journal of gastrointestinal surgery2026
Spatial immune cell architecture after gastric cancer surgery predicts prognosis.
Article in World journal of gastrointestinal surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- CSN3 promotes gastric cancer progression and is associated with immune infiltration and inflammatory signaling.Translational cancer research · 2026Article
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Abstract
backgroundGastric cancer remains a major global health burden with high mortality due to late-stage diagnosis and limited treatment efficacy. Emerging evidence demonstrates that the tumor microenvironment, particularly immune cell infiltration patterns and hypoxia-induced immunosuppression, plays a critical role in cancer progression. This study investigates the spatial immune cell architecture in postoperative gastric cancer tissues to identify prognostic biomarkers and guide personalized immunotherapy strategies.
aimTo investigate the spatial distribution pattern, density, and proportional features of important immune cells in the tumor microenvironment following radical gastrectomy for gastric cancer, assess their relationships with patients' 5-year overall survival (OS) and recurrence-free survival following surgery, and provide an immunological foundation for prognostic assessment.
methodsA total of 112 patients with stage I-III gastric cancer who underwent R0 resection between June 2018 and June 2020 were included retrospectively. Paraffin-embedded specimens of postoperative cancer tissues and adjacent tissues were collected. The multicolor immunohistochemistry technique was used, and pan-cytokeratin staining was performed synchronously with 4,6-diamidino-2-phenylindole nuclear staining. The sections were scanned by the Vectra Polaris™ full-spectrum imaging system, and cell phenotype identification and spatial localization analysis were performed
resultsThe density of CD8+ T cells in the invasion margin area (median: 248.5/mm
conclusionThe spatial distribution pattern of immune cells in the tumor microenvironment following gastric cancer surgery and the percentages of particular subgroups (programmed death ligand 1+ and CD8+/FoxP3+ tumor cells) are independent predictors of long-term survival.
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