ArticleAsian journal of pharmaceutical sciences2025
A self-assembled nano-spray formulation for synergistic therapy of anti-inflammation and skin repair.
Article in Asian journal of pharmaceutical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Reduction of Ultraviolet- and Heat-Induced Aging Using Betulin-Loaded Arginine-Caprylate Self-Assembly: Randomized Double-Blind Clinical Trials.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2026Trial
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inflammatory skin disorders (ISDs), characterized by severe inflammation and impaired skin barrier functions, often requires persistent treatment due to chronic and relapsing natures. To address these issues, we developed a small-molecular self-assembled nanodrug (ECN) that is composed of natural epigallocatechin-3-gallate (EGCG) self-assembled with tripeptide collagen (CTP). By formulating a transdermal enhancer (cationic dendrimer) with ECN, the resulted dendrimers/ECN nanocomplex (DECN) can effectively penetrate into the skin layer, resulting in effective anti-inflammatory response and repair of skin-barrier functions. In animal models of ISDs, including atopic dermatitis (AD) and psoriasis, DECN showed remarkable skin penetration, with high level of drug deposition in the epidermal-dermal layer. By using a commercially available spray pump, DECN nanoparticles can be further translated into a spray formulation, which contributes to alleviating visible symptoms, skin lesions, and inflammatory progression of psoriasis and AD. This all-in-one spray nano-formulation offers an effective, safe, and convenient way for ISDs treatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.