Evidence map›Paper›PMID 41809255›Full record

ReviewAsian journal of pharmaceutical sciences2025

Macrophage-centered therapy strategies: A promising weapon in cancer immunotherapy.

Simiao Wang, Jiayi Liu, Yaxin Cui, Man Sun, Wei Wang, Jiayi Chen, Jingkai Gu, Zhaogang Yang

Abstract readReview
In one paragraph

Review in Asian journal of pharmaceutical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Biomimetic nanotherapy forInternational journal of pharmaceutics: X · 2025
    Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Simiao WangSchool of Life Sciences, Jilin University, Changchun 130012, China.
Jiayi LiuSchool of Life Sciences, Jilin University, Changchun 130012, China.
Yaxin CuiSchool of Life Sciences, Jilin University, Changchun 130012, China.
Man SunSchool of Life Sciences, Jilin University, Changchun 130012, China.
Wei WangDepartment of Chemistry, University of Bergen, Bergen 5007, Norway.
Jiayi ChenSchool of Life Sciences, Jilin University, Changchun 130012, China.
Jingkai GuSchool of Life Sciences, Jilin University, Changchun 130012, China.
Zhaogang YangSchool of Life Sciences, Jilin University, Changchun 130012, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Macrophages are critical phagocytes in the immune system, and tumor-infiltrating macrophages can substantially influence the efficacy and prognosis of immunotherapy. Therefore, macrophages may serve as therapeutic targets for modulating the tumor immune microenvironment. Macrophage-based drug delivery systems have been extensively evaluated owing to their excellent biocompatibility, long half-life, and inherent ability to migrate and accumulate at sites of inflammation, such as tumors. Live macrophages and their membrane coatings contain abundant receptor proteins that facilitate payload transport across physiological barriers. In this review, we discuss strategies that utilize macrophages as targets and delivery carriers for cancer immunotherapy. Here, we summarize the different macrophage phenotypes, tumor-associated macrophage-targeting strategies, and biomimetic delivery carriers derived from macrophages used in immunotherapy. Overall, macrophage-centered strategies for cancer therapy hold considerable promise for clinical applications.

Indexed as

Drug delivery systemExtracellular vesiclesImmunotherapyMacrophagesMembrane coatings

Identifiers

PMID41809255
PMCPMC12552155

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.